Email this article Synthesis of an Acyclic Precursor to Epothilone D Analog. Aldol Condensation of (1R)-1-(1,3-Dithiolan-2-yl)-1-(methoxymethoxy)- 2,2-dimethylpentan-3-one with C6‒C21 and C6‒C9 Aldehyde Segments
- Authors: Valeev R.F.1, Sunagatullina G.R.1, Loza V.V.1, Miftakhov M.S.1
-
Affiliations:
- Ufa Institute of Chemistry, Ufa Federal Research Center
- Issue: Vol 54, No 10 (2018)
- Pages: 1548-1552
- Section: Article
- URL: https://bakhtiniada.ru/1070-4280/article/view/219284
- DOI: https://doi.org/10.1134/S1070428018100172
- ID: 219284
Cite item
Open Access
Access granted
Subscription Access
Abstract
The synthesis of acyclic precursors to epothilone D analogs has been explored. Optimal conditions have been found for enolization of (1R)-1-(1,3-dithiolan-2-yl)-1-(methoxymethoxy)-2,2-dimethylpentan-3-one and its aldol condensation with C6‒C21 and C6‒C9 aldehydes.
About the authors
R. F. Valeev
Ufa Institute of Chemistry, Ufa Federal Research Center
Author for correspondence.
Email: rusl0@yandex.ru
Russian Federation, pr. Oktyabrya 71, Ufa, Bashkortostan, 450054
G. R. Sunagatullina
Ufa Institute of Chemistry, Ufa Federal Research Center
Email: rusl0@yandex.ru
Russian Federation, pr. Oktyabrya 71, Ufa, Bashkortostan, 450054
V. V. Loza
Ufa Institute of Chemistry, Ufa Federal Research Center
Email: rusl0@yandex.ru
Russian Federation, pr. Oktyabrya 71, Ufa, Bashkortostan, 450054
M. S. Miftakhov
Ufa Institute of Chemistry, Ufa Federal Research Center
Email: rusl0@yandex.ru
Russian Federation, pr. Oktyabrya 71, Ufa, Bashkortostan, 450054
Supplementary files
