Enviar artigo por via de e-mail Synthesis and Anticholinesterase Activity of [(4Z)-2-Aryl-4-(arylmethylidene)-5-oxo-4,5-dihydro-1H-imidazol-1-yl]alkanoic Acids
- Autores: Topuzyan V.O.1, Kazoyan V.M.1, Tamazyan R.A.1, Aivazyan A.G.1, Galstyan L.K.2
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Afiliações:
- Scientific Technological Center of Organic and Pharmaceutical Chemistry
- Yerevan State University
- Edição: Volume 54, Nº 9 (2018)
- Páginas: 1369-1377
- Seção: Article
- URL: https://bakhtiniada.ru/1070-4280/article/view/218949
- DOI: https://doi.org/10.1134/S1070428018090178
- ID: 218949
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Resumo
ω-[(4Z)-2-Aryl-4-arylmethylidene-5-oxo-4,5-dihydro-1H-imidazol-1-yl]alkanoic acids were synthesized by reaction of N-substituted α,β-dehydropeptides with chloro(trimethyl)silane or 1,1,1,3,3,3-hexamethyldisilazane. Both initial peptides and (4H)-imidazol-5-one derivatives based thereon were tested for anticholinesterase activity.
Sobre autores
V. Topuzyan
Scientific Technological Center of Organic and Pharmaceutical Chemistry
Autor responsável pela correspondência
Email: vtop@web.am
Armênia, pr. Azatutyan 26, Yerevan, 0014
V. Kazoyan
Scientific Technological Center of Organic and Pharmaceutical Chemistry
Email: vtop@web.am
Armênia, pr. Azatutyan 26, Yerevan, 0014
R. Tamazyan
Scientific Technological Center of Organic and Pharmaceutical Chemistry
Email: vtop@web.am
Armênia, pr. Azatutyan 26, Yerevan, 0014
A. Aivazyan
Scientific Technological Center of Organic and Pharmaceutical Chemistry
Email: vtop@web.am
Armênia, pr. Azatutyan 26, Yerevan, 0014
L. Galstyan
Yerevan State University
Email: vtop@web.am
Armênia, ul. Aleka Manukyana 1, Yerevan, 0025
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