Synthesis of 2,5-diaryl-1,3-oxazoles containing a carbamate group
- 作者: Velikorodov A.V.1, Shustova E.A.1, Nosachev S.B.1
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隶属关系:
- Astrakhan State University
- 期: 卷 53, 编号 12 (2017)
- 页面: 1857-1859
- 栏目: Article
- URL: https://bakhtiniada.ru/1070-4280/article/view/217040
- DOI: https://doi.org/10.1134/S1070428017120120
- ID: 217040
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详细
Acetophenones containing a methoxycarbonylamino group in position 2, 3, or 4 of the aromatic ring reacted with phenylglycine in the presence of 2 equiv of iodine and 0.5 equiv of sulfanilic acid in DMSO at 100°C for 6 h to give methyl [2(3,4)-(2-phenyl-1,3-oxazol-5-yl)phenyl]carbamates. The reaction was presumed to involve intermediate formation of methyl [(iodoacetyl)phenyl]carbamate. This was confirmed by the isolation of methyl [2-(iodoacetyl)phenyl]carbamate in the reaction of methyl (2-acetylphenyl)carbamate with iodine in glacial acetic acid and its subsequent transformation to methyl [2-(2-phenyl-1,3-oxazol-5-yl)-phenyl]carbamate.
作者简介
A. Velikorodov
Astrakhan State University
编辑信件的主要联系方式.
Email: avelikorodov@mail.ru
俄罗斯联邦, pl. Shaumyana 1, Astrakhan, 414000
E. Shustova
Astrakhan State University
Email: avelikorodov@mail.ru
俄罗斯联邦, pl. Shaumyana 1, Astrakhan, 414000
S. Nosachev
Astrakhan State University
Email: avelikorodov@mail.ru
俄罗斯联邦, pl. Shaumyana 1, Astrakhan, 414000
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