Three-component heterocyclization of 5-(arylmethylidene)pyrimidine-2,4,6(1H,3H,5H)-triones with aldehydes and amino acids


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Abstract

Previously unknown substituted 4-aryl-2,7,9-triazaspiro[4.5]decane-6,8,10-triones were synthesized in 50–70% yield by heating 5-(arylmethylidene)barbituric acids with N-methyl- or N-phenylglycine and para-formaldehyde or 4-methoxybenzaldehyde in boiling toluene for 14 h.

About the authors

A. G. Tyrkov

Astrakhan State University

Author for correspondence.
Email: tyrkov@rambler.ru
Russian Federation, pl. Shaumyana 1, Astrakhan, 414000

E. A. Yurtaeva

Astrakhan State University

Email: tyrkov@rambler.ru
Russian Federation, pl. Shaumyana 1, Astrakhan, 414000

L. A. Dan’kova

Astrakhan State University

Email: tyrkov@rambler.ru
Russian Federation, pl. Shaumyana 1, Astrakhan, 414000

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