Reaction of 2-hydroxy-N′-[(4-oxo-4H-chromen-3-yl)methylidene]benzohydrazide with some phosphorus reagents. Synthesis and evaluation of anticancer activity of novel α-hydrazinophosphonic acid, 1,4,5,2λ5-oxadiazaphosphinines, and 1,3,2λ5-benzoxazaphosphinines bearing a chromone ring
- Авторлар: Ali T.E.1, Ali M.M.2, Abdel-Kariem S.M.1, Ahmed M.M.1
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Мекемелер:
- Department of Chemistry, Faculty of Education
- Department of Biochemistry, Division of Genetic Engineering and Biotechnology
- Шығарылым: Том 53, № 6 (2017)
- Беттер: 904-912
- Бөлім: Article
- URL: https://bakhtiniada.ru/1070-4280/article/view/216392
- DOI: https://doi.org/10.1134/S107042801706015X
- ID: 216392
Дәйексөз келтіру
Аннотация
Novel 1,4,5,2-Oxadiazaphosphinines, 1,3,2-benzoxazaphosphinines, and α-hydrazinophosphonic acid bearing a chromone ring were obtained by reactions of 2-hydroxy-N′-[(4-oxo-4H-chromen-3-yl)-methylidene]benzohydrazide with some phosphorus reagents such as phosphonic acid and its esters, phosphorus sulfides, and phosphorus halides. The synthesized compounds were evaluated for their anticancer activity against four cancer cell lines. Two compounds exhibited high effects against MCF-7 breast cancer cells and on the expression of VEGF inhibition.
Авторлар туралы
T. Ali
Department of Chemistry, Faculty of Education
Хат алмасуға жауапты Автор.
Email: tarik_elsayed1975@yahoo.com
Египет, Roxy, Cairo
M. Ali
Department of Biochemistry, Division of Genetic Engineering and Biotechnology
Email: tarik_elsayed1975@yahoo.com
Египет, Giza
S. Abdel-Kariem
Department of Chemistry, Faculty of Education
Email: tarik_elsayed1975@yahoo.com
Египет, Roxy, Cairo
M. Ahmed
Department of Chemistry, Faculty of Education
Email: tarik_elsayed1975@yahoo.com
Египет, Roxy, Cairo
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