7α-alkylation, 7,7-bisalkylation, and reduction of the 20-oxo group of poststerone in reactions with alkyl halides in lithium–ammonia solution
- 作者: Galyautdinov I.V.1, Sadretdinova Z.R.1, Mozgovoi O.S.1, Gibadullina G.G.1, Khalilov L.M.1, Muslimov Z.S.1, Odinokov V.N.1
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隶属关系:
- Institute of Petrochemistry and Catalysis
- 期: 卷 53, 编号 1 (2017)
- 页面: 109-117
- 栏目: Article
- URL: https://bakhtiniada.ru/1070-4280/article/view/215673
- DOI: https://doi.org/10.1134/S1070428017010201
- ID: 215673
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详细
Reactions of poststerone with methyl iodide, allyl bromide, and propargyl bromide in lithium–ammonia solution resulted in its completely stereoselective 7α-alkylation accompanied by reduction of the 20-oxo group with formation of equimolar amounts of 20R- and 20S-hydroxy derivatives. The reaction of poststerone with excess allyl bromide afforded 7,7-bis-allyl 20R- and 20S-alcohols at a ratio of 3: 1. The reduction of the 20-oxo group in the alkylation of poststerone with excess propargyl bromide led to the formation of an equimolar mixture of Δ8(14)- and Δ8(9)-isomers with exclusive S configuration of C20.
作者简介
I. Galyautdinov
Institute of Petrochemistry and Catalysis
Email: ilgizphd@mail.ru
俄罗斯联邦, pr. Oktyabrya 141, Ufa, Bashkortostan, 450075
Z. Sadretdinova
Institute of Petrochemistry and Catalysis
Email: ilgizphd@mail.ru
俄罗斯联邦, pr. Oktyabrya 141, Ufa, Bashkortostan, 450075
O. Mozgovoi
Institute of Petrochemistry and Catalysis
Email: ilgizphd@mail.ru
俄罗斯联邦, pr. Oktyabrya 141, Ufa, Bashkortostan, 450075
G. Gibadullina
Institute of Petrochemistry and Catalysis
Email: ilgizphd@mail.ru
俄罗斯联邦, pr. Oktyabrya 141, Ufa, Bashkortostan, 450075
L. Khalilov
Institute of Petrochemistry and Catalysis
Email: ilgizphd@mail.ru
俄罗斯联邦, pr. Oktyabrya 141, Ufa, Bashkortostan, 450075
Z. Muslimov
Institute of Petrochemistry and Catalysis
Email: ilgizphd@mail.ru
俄罗斯联邦, pr. Oktyabrya 141, Ufa, Bashkortostan, 450075
V. Odinokov
Institute of Petrochemistry and Catalysis
编辑信件的主要联系方式.
Email: ilgizphd@mail.ru
俄罗斯联邦, pr. Oktyabrya 141, Ufa, Bashkortostan, 450075
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