Synthesis of 1,5,6,7-tetrahydro-4H-benzimidazol-4-one derivatives from 2,6-bis(hydroxyimino)cyclohexan-1-one
- 作者: Samsonov V.A.1
-
隶属关系:
- Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch
- 期: 卷 53, 编号 1 (2017)
- 页面: 66-73
- 栏目: Article
- URL: https://bakhtiniada.ru/1070-4280/article/view/215629
- DOI: https://doi.org/10.1134/S1070428017010122
- ID: 215629
如何引用文章
详细
The reaction of 2,6-bis(hydroxyimino)cyclohexan-1-one with aldehydes and ammonia afforded 2-substituted 4-hydroxyimino-4,5,6,7-tetrahydro-1H-benzimidazol-1-ols which were hydrolyzed to 1-hydroxy- 2-R-1,5,6,7-tetrahydro-4H-benzimidazol-4-ones. The N-hydroxy group in the latter can readily by removed by the action of chloroacetone in the presence of a base (potassium carbonate or triethylamine); as a result, 2-substituted 1,5,6,7-tetrahydro-4H-benzimidazol-4-ones were obtained.
作者简介
V. Samsonov
Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch
编辑信件的主要联系方式.
Email: samson@nioch.nsc.ru
俄罗斯联邦, pr. Akademika Lavrent’eva 9, Novosibirsk, 630090
补充文件
