Synthesis of spiro[imidazole-2,2′-pyrroles] by reaction of 4,5-dioxo-4,5-dihydro-1 H -pyrrole-2-carboxylates with urea

A. Yu. Dubovtsev; P. S. Silaichev; M. A. Zheleznova; Z. G. Aliev; A. N. Maslivets

doi:10.1134/S1070428016120113

Synthesis of spiro[imidazole-2,2′-pyrroles] by reaction of 4,5-dioxo-4,5-dihydro-1H-pyrrole-2-carboxylates with urea

Authors: Dubovtsev A.Y.¹, Silaichev P.S.¹, Zheleznova M.A.¹, Aliev Z.G.², Maslivets A.N.¹
Affiliations:
1. Perm State National Research University
2. Institute of Chemical Physics Problems
Issue: Vol 52, No 12 (2016)
Pages: 1779-1783
Section: Article
URL: https://bakhtiniada.ru/1070-4280/article/view/215435
DOI: https://doi.org/10.1134/S1070428016120113
ID: 215435

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Abstract

Substituted alkyl 4,5-dioxo-4,5-dihydro-1H-pyrrole-2-carboxylates reacted with urea to give alkyl 2-(carbamoylamino)-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-2-carboxylates which underwent intramolecular cyclization to 8-hydroxy-1,3,6-triazaspiro[4.4]non-8-ene-2,4,7-triones by the action of sodium methoxide.