Behavioral Activity of Rats in Experimental Hypothyreosis and Its Correction with Iodine-Containing Drugs

Abstract

Abstract—Behavioral activity of rats in experimental hypothyreosis and its correction with iodine-containing drugs was investigated. It has been demonstrated that the administration of thyrostatic mercazolilum to white rats for 8 weeks leads to experimental hypothyreosis accompanied by a decrease in thyroxine (T4) level to 5.25 ng/mL and an increase in thyroid-stimulating hormone (TSH) level to 8.75 ng/mL. In the control (healthy) animals, the average levels of T4 and TSH were 43.70 and 1.73 ng/mL, respectively. When the animals with experimental hypothyreosis received an intramuscular injection of iodine-containing drugs (Sedimin-Fe⁺ and Sedimin-Se⁺) twice with an interval of 10 days and a preparation of bio-iron with microelements orally for 20 days, the level of thyroxine rose to 52.7 ± 3.48 and 54.8 ± 4.17 ng/mL in response to Sedimin-Fe⁺ and Sedimin-Se⁺ administration, respectively, and to 56.2 ± 4.13 ng/mL after the ingestion of feed enriched with bio-iron and microelements. In animals that did not receive the drugs, the T4 level was 5.25 ± 0.55 ng/mL. The levels of thyroid-stimulating hormone after the treatment with iodine-containing preparations were 0.37 ± 0.14, 0.51 ± 0.18, 0.47 ± 0.15, and 8.75 ± 0.55 ng/mL for Sedimin-Fe⁺, Sedimin-Se⁺, bio-iron with microelements, and animals with experimental hypothyreosis, respectively.