Enviar artigo por via de e-mail New Ionic Conjugates Based on α-Tocopheryl Succinate as Potential Cytotoxic Agents
- Autores: Frolova T.S.1,2,3, Sharapov S.Z.2,3, Sinitsyna O.I.2,3, Tolstikova T.G.1,3, Grigoriev I.A.1,4, Morozov S.V.1,3, Yushkova Y.V.1
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Afiliações:
- Novosibirsk Institute of Organic Chemistry, Siberian Branch
- Institute of Cytology and Genetics, Siberian Branch
- Novosibirsk State University
- Meshalkin State Research Institute of Circulation Pathology
- Edição: Volume 44, Nº 3 (2018)
- Páginas: 330-336
- Seção: Article
- URL: https://bakhtiniada.ru/1068-1620/article/view/228935
- DOI: https://doi.org/10.1134/S1068162018030068
- ID: 228935
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Resumo
Five new ionic conjugates based on α-tocopheryl succinate were synthesized, including amino- TEMPO, cytisine, convolvin, amantadine, and rimantadine as functional groups. Using bacterial test systems, the safety of the compounds obtained was shown, and antioxidant properties were studied. Investigation of the cytotoxic properties of synthesized conjugates with a chromane skeleton revealed their selectivity to the MCF7 breast cancer line, the effect was most pronounced for derivatives with amino-TEMPO and rimantadine fragments.
Sobre autores
T. Frolova
Novosibirsk Institute of Organic Chemistry, Siberian Branch; Institute of Cytology and Genetics, Siberian Branch; Novosibirsk State University
Autor responsável pela correspondência
Email: frolova@nioch.nsc.ru
Rússia, Novosibirsk, 630090; Novosibirsk, 630090; Novosibirsk, 630090
S. Sharapov
Institute of Cytology and Genetics, Siberian Branch; Novosibirsk State University
Email: frolova@nioch.nsc.ru
Rússia, Novosibirsk, 630090; Novosibirsk, 630090
O. Sinitsyna
Institute of Cytology and Genetics, Siberian Branch; Novosibirsk State University
Email: frolova@nioch.nsc.ru
Rússia, Novosibirsk, 630090; Novosibirsk, 630090
T. Tolstikova
Novosibirsk Institute of Organic Chemistry, Siberian Branch; Novosibirsk State University
Email: frolova@nioch.nsc.ru
Rússia, Novosibirsk, 630090; Novosibirsk, 630090
I. Grigoriev
Novosibirsk Institute of Organic Chemistry, Siberian Branch; Meshalkin State Research Institute of Circulation Pathology
Email: frolova@nioch.nsc.ru
Rússia, Novosibirsk, 630090; Novosibirsk
S. Morozov
Novosibirsk Institute of Organic Chemistry, Siberian Branch; Novosibirsk State University
Email: frolova@nioch.nsc.ru
Rússia, Novosibirsk, 630090; Novosibirsk, 630090
Y. Yushkova
Novosibirsk Institute of Organic Chemistry, Siberian Branch
Email: frolova@nioch.nsc.ru
Rússia, Novosibirsk, 630090
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