Мақаланы E-mail арқылы жіберу Investigation of the complex antibiotic INA-5812
- Авторлар: Lapchinskaya O.A.1, Katrukha G.S.1, Gladkikh E.G.1, Kulyaeva V.V.1, Coodan P.V.2, Topolyan A.P.3, Alferova V.A.1, Pogozheva V.V.1, Sukonnikov M.A.4, Rogozhin E.A.1,3, Prokhorenko I.A.1,3, Brylev V.A.3, Korolev A.M.1, Slyundina M.S.1,5, Borisov R.S.5,6, Serebryakova M.V.7, Shuvalov M.V.1,4, Ksenofontov A.L.7, Stoyanova L.G.8, Osterman I.A.4,7, Formanovsky A.A.3, Tashlitsky V.N.4, Baratova L.A.7, Timofeeva A.V.7, Tyurin A.P.1,3
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Мекемелер:
- Gause Institute of New Antibiotics
- Federal Research Center of Nutrition and Biotechnology
- Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
- Faculty of Chemistry
- Topchiev Institute of Petrochemical Synthesis
- Faculty of Physics, Mathematics and Natural Sciences
- Belozersky Institute of Physico-Chemical Biology
- Faculty of Biology
- Шығарылым: Том 42, № 6 (2016)
- Беттер: 664-671
- Бөлім: Article
- URL: https://bakhtiniada.ru/1068-1620/article/view/228225
- DOI: https://doi.org/10.1134/S1068162016060078
- ID: 228225
Дәйексөз келтіру
Ашық рұқсат
Рұқсат берілді
Тек жазылушылар үшін
Аннотация
A concentrate with the antimicrobial activity has been isolated from the culture broth of Streptomyces roseoflavus INA-Ac-5812. Its further fractionation by reversed-phase HPLC has resulted in six fractions. It has been established by MALDI-TOF and ESI-MSn precision mass-spectrometry methods that the main components of the complex antibiotic are several closely related compounds, presumably of a glycopeptide nature. The fraction containing an individual component with a mass of 1845.788 Da has been characterized by UV/Vis absorbance and fluorescence spectra, amino acid analysis, and derivatization with tris(2,6-dimethoxyphenyl)methyl cation. The activity of fractions against pathogenic microbes has been studied. The results allow the supposition that the INA-5812 antibiotic complex is a glyco- or lipoglycopeptide antibiotic of a new type, which is very promising for further study.
Авторлар туралы
O. Lapchinskaya
Gause Institute of New Antibiotics
Email: ap2rin@gmail.com
Ресей, Moscow, 119021
G. Katrukha
Gause Institute of New Antibiotics
Email: ap2rin@gmail.com
Ресей, Moscow, 119021
E. Gladkikh
Gause Institute of New Antibiotics
Email: ap2rin@gmail.com
Ресей, Moscow, 119021
V. Kulyaeva
Gause Institute of New Antibiotics
Email: ap2rin@gmail.com
Ресей, Moscow, 119021
P. Coodan
Federal Research Center of Nutrition and Biotechnology
Email: ap2rin@gmail.com
Ресей, Moscow, 109240
A. Topolyan
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: ap2rin@gmail.com
Ресей, Moscow, 117997
V. Alferova
Gause Institute of New Antibiotics
Email: ap2rin@gmail.com
Ресей, Moscow, 119021
V. Pogozheva
Gause Institute of New Antibiotics
Email: ap2rin@gmail.com
Ресей, Moscow, 119021
M. Sukonnikov
Faculty of Chemistry
Email: ap2rin@gmail.com
Ресей, Moscow, 119991
E. Rogozhin
Gause Institute of New Antibiotics; Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: ap2rin@gmail.com
Ресей, Moscow, 119021; Moscow, 117997
I. Prokhorenko
Gause Institute of New Antibiotics; Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: ap2rin@gmail.com
Ресей, Moscow, 119021; Moscow, 117997
V. Brylev
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: ap2rin@gmail.com
Ресей, Moscow, 117997
A. Korolev
Gause Institute of New Antibiotics
Email: ap2rin@gmail.com
Ресей, Moscow, 119021
M. Slyundina
Gause Institute of New Antibiotics; Topchiev Institute of Petrochemical Synthesis
Email: ap2rin@gmail.com
Ресей, Moscow, 119021; Moscow, 119991
R. Borisov
Topchiev Institute of Petrochemical Synthesis; Faculty of Physics, Mathematics and Natural Sciences
Email: ap2rin@gmail.com
Ресей, Moscow, 119991; Moscow, 115419
M. Serebryakova
Belozersky Institute of Physico-Chemical Biology
Email: ap2rin@gmail.com
Ресей, Moscow, 119992
M. Shuvalov
Gause Institute of New Antibiotics; Faculty of Chemistry
Email: ap2rin@gmail.com
Ресей, Moscow, 119021; Moscow, 119991
A. Ksenofontov
Belozersky Institute of Physico-Chemical Biology
Email: ap2rin@gmail.com
Ресей, Moscow, 119992
L. Stoyanova
Faculty of Biology
Email: ap2rin@gmail.com
Ресей, Moscow, 119991
I. Osterman
Faculty of Chemistry; Belozersky Institute of Physico-Chemical Biology
Email: ap2rin@gmail.com
Ресей, Moscow, 119991; Moscow, 119992
A. Formanovsky
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: ap2rin@gmail.com
Ресей, Moscow, 117997
V. Tashlitsky
Faculty of Chemistry
Email: ap2rin@gmail.com
Ресей, Moscow, 119991
L. Baratova
Belozersky Institute of Physico-Chemical Biology
Email: ap2rin@gmail.com
Ресей, Moscow, 119992
A. Timofeeva
Belozersky Institute of Physico-Chemical Biology
Email: ap2rin@gmail.com
Ресей, Moscow, 119992
A. Tyurin
Gause Institute of New Antibiotics; Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Хат алмасуға жауапты Автор.
Email: ap2rin@gmail.com
Ресей, Moscow, 119021; Moscow, 117997
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