Asymmetric Ir-catalyzed hydrogenation of 1,3-dihydro-2H-1,5-benzodiazepin-2-ones using phosphoramidites


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A series of phosphoramidite ligands was tested in the asymmetric hydrogenation of 4-arylsubstituted 1,3-dihydro-2H-benzodiazepine-2-ones and up to 52% ee was achieved. The effects of various factors (solvents, hydrogen pressure, and addition of phosphine ligands) on the hydrogenation were studied.

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M. Sokolovskaya

A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences

Email: lssp452@mail.ru
俄罗斯联邦, 28 ul. Vavilova, Moscow, 119991

S. Lyubimov

A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences

编辑信件的主要联系方式.
Email: lssp452@mail.ru
俄罗斯联邦, 28 ul. Vavilova, Moscow, 119991

I. Mikhel

A. N. Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences

Email: lssp452@mail.ru
俄罗斯联邦, 31/4 Leninsky prosp., Moscow, 119071

K. Birin

A. N. Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences

Email: lssp452@mail.ru
俄罗斯联邦, 31/4 Leninsky prosp., Moscow, 119071

V. Davankov

A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences

Email: lssp452@mail.ru
俄罗斯联邦, 28 ul. Vavilova, Moscow, 119991

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