Email this article Asymmetric Ir-catalyzed hydrogenation of 1,3-dihydro-2H-1,5-benzodiazepin-2-ones using phosphoramidites
- Authors: Sokolovskaya M.V.1, Lyubimov S.E.1, Mikhel I.S.2, Birin K.P.2, Davankov V.A.1
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Affiliations:
- A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences
- A. N. Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences
- Issue: Vol 67, No 2 (2018)
- Pages: 260-264
- Section: Full Articles
- URL: https://bakhtiniada.ru/1066-5285/article/view/242116
- DOI: https://doi.org/10.1007/s11172-018-2068-9
- ID: 242116
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Abstract
A series of phosphoramidite ligands was tested in the asymmetric hydrogenation of 4-arylsubstituted 1,3-dihydro-2H-benzodiazepine-2-ones and up to 52% ee was achieved. The effects of various factors (solvents, hydrogen pressure, and addition of phosphine ligands) on the hydrogenation were studied.
About the authors
M. V. Sokolovskaya
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences
Email: lssp452@mail.ru
Russian Federation, 28 ul. Vavilova, Moscow, 119991
S. E. Lyubimov
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences
Author for correspondence.
Email: lssp452@mail.ru
Russian Federation, 28 ul. Vavilova, Moscow, 119991
I. S. Mikhel
A. N. Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences
Email: lssp452@mail.ru
Russian Federation, 31/4 Leninsky prosp., Moscow, 119071
K. P. Birin
A. N. Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences
Email: lssp452@mail.ru
Russian Federation, 31/4 Leninsky prosp., Moscow, 119071
V. A. Davankov
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences
Email: lssp452@mail.ru
Russian Federation, 28 ul. Vavilova, Moscow, 119991
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