Enviar artigo por via de e-mail Formulation of perspective hepatoprotector polymeric forms based on silybin and ursodeoxycholic acid
- Autores: Tereshchenko O.G.1, Nikolskaya E.D.1, Zhunina O.A.1, Zavarzina V.V.2, Yabbarov N.G.1, Fomicheva M.V.1, Zubkov E.V.1,3, Sokol M.B.1, Gukasova N.V.2, Severin E.S.1
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Afiliações:
- Russian Research Center for Molecular Diagnostics and Therapy
- National Research Center “Kurchatov Institute”
- Sechenov University, Ministry of Health of the Russian Federation
- Edição: Volume 67, Nº 12 (2018)
- Páginas: 2290-2296
- Seção: Full Articles
- URL: https://bakhtiniada.ru/1066-5285/article/view/243233
- DOI: https://doi.org/10.1007/s11172-018-2372-4
- ID: 243233
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Resumo
Silybin (Slb) and ursodeoxycholic acid (UDCA) are hepatoprotectors used in the pathogenetic therapy of liver and biliary tract. However, low bioavailability of these drugs restricts their application. In order to solve this problem, Slb and UDCA were incorporated into polymer carriers based on polylactic acid and poly(lactic-co-glycolic acid) by nanoprecipitation. The polymeric forms obtained according to the developed and optimized method are nanoparticles with a size from 100 to 200 μm. In vitro experiments showed a 1.5–2-fold higher hepatoprotective activity of Slb- and UDCA-containing polymeric nanoparticles compared to free substances.
Sobre autores
O. Tereshchenko
Russian Research Center for Molecular Diagnostics and Therapy
Email: e.severin@mail.ru
Rússia, 8 Simferopol´skii b-r, Moscow, 117638
E. Nikolskaya
Russian Research Center for Molecular Diagnostics and Therapy
Email: e.severin@mail.ru
Rússia, 8 Simferopol´skii b-r, Moscow, 117638
O. Zhunina
Russian Research Center for Molecular Diagnostics and Therapy
Autor responsável pela correspondência
Email: e.severin@mail.ru
Rússia, 8 Simferopol´skii b-r, Moscow, 117638
V. Zavarzina
National Research Center “Kurchatov Institute”
Email: e.severin@mail.ru
Rússia, 1 pl. Akad. Kurchatova, Moscow, 123098
N. Yabbarov
Russian Research Center for Molecular Diagnostics and Therapy
Email: e.severin@mail.ru
Rússia, 8 Simferopol´skii b-r, Moscow, 117638
M. Fomicheva
Russian Research Center for Molecular Diagnostics and Therapy
Email: e.severin@mail.ru
Rússia, 8 Simferopol´skii b-r, Moscow, 117638
E. Zubkov
Russian Research Center for Molecular Diagnostics and Therapy; Sechenov University, Ministry of Health of the Russian Federation
Email: e.severin@mail.ru
Rússia, 8 Simferopol´skii b-r, Moscow, 117638; 2 Build., 8 ul. Trubetskaya, Moscow, 119991
M. Sokol
Russian Research Center for Molecular Diagnostics and Therapy
Email: e.severin@mail.ru
Rússia, 8 Simferopol´skii b-r, Moscow, 117638
N. Gukasova
National Research Center “Kurchatov Institute”
Email: e.severin@mail.ru
Rússia, 1 pl. Akad. Kurchatova, Moscow, 123098
E. Severin
Russian Research Center for Molecular Diagnostics and Therapy
Email: e.severin@mail.ru
Rússia, 8 Simferopol´skii b-r, Moscow, 117638
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