Отправить статью по E-mail Formulation of perspective hepatoprotector polymeric forms based on silybin and ursodeoxycholic acid
- Авторы: Tereshchenko O.G.1, Nikolskaya E.D.1, Zhunina O.A.1, Zavarzina V.V.2, Yabbarov N.G.1, Fomicheva M.V.1, Zubkov E.V.1,3, Sokol M.B.1, Gukasova N.V.2, Severin E.S.1
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Учреждения:
- Russian Research Center for Molecular Diagnostics and Therapy
- National Research Center “Kurchatov Institute”
- Sechenov University, Ministry of Health of the Russian Federation
- Выпуск: Том 67, № 12 (2018)
- Страницы: 2290-2296
- Раздел: Full Articles
- URL: https://bakhtiniada.ru/1066-5285/article/view/243233
- DOI: https://doi.org/10.1007/s11172-018-2372-4
- ID: 243233
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Аннотация
Silybin (Slb) and ursodeoxycholic acid (UDCA) are hepatoprotectors used in the pathogenetic therapy of liver and biliary tract. However, low bioavailability of these drugs restricts their application. In order to solve this problem, Slb and UDCA were incorporated into polymer carriers based on polylactic acid and poly(lactic-co-glycolic acid) by nanoprecipitation. The polymeric forms obtained according to the developed and optimized method are nanoparticles with a size from 100 to 200 μm. In vitro experiments showed a 1.5–2-fold higher hepatoprotective activity of Slb- and UDCA-containing polymeric nanoparticles compared to free substances.
Об авторах
O. Tereshchenko
Russian Research Center for Molecular Diagnostics and Therapy
Email: e.severin@mail.ru
Россия, 8 Simferopol´skii b-r, Moscow, 117638
E. Nikolskaya
Russian Research Center for Molecular Diagnostics and Therapy
Email: e.severin@mail.ru
Россия, 8 Simferopol´skii b-r, Moscow, 117638
O. Zhunina
Russian Research Center for Molecular Diagnostics and Therapy
Автор, ответственный за переписку.
Email: e.severin@mail.ru
Россия, 8 Simferopol´skii b-r, Moscow, 117638
V. Zavarzina
National Research Center “Kurchatov Institute”
Email: e.severin@mail.ru
Россия, 1 pl. Akad. Kurchatova, Moscow, 123098
N. Yabbarov
Russian Research Center for Molecular Diagnostics and Therapy
Email: e.severin@mail.ru
Россия, 8 Simferopol´skii b-r, Moscow, 117638
M. Fomicheva
Russian Research Center for Molecular Diagnostics and Therapy
Email: e.severin@mail.ru
Россия, 8 Simferopol´skii b-r, Moscow, 117638
E. Zubkov
Russian Research Center for Molecular Diagnostics and Therapy; Sechenov University, Ministry of Health of the Russian Federation
Email: e.severin@mail.ru
Россия, 8 Simferopol´skii b-r, Moscow, 117638; 2 Build., 8 ul. Trubetskaya, Moscow, 119991
M. Sokol
Russian Research Center for Molecular Diagnostics and Therapy
Email: e.severin@mail.ru
Россия, 8 Simferopol´skii b-r, Moscow, 117638
N. Gukasova
National Research Center “Kurchatov Institute”
Email: e.severin@mail.ru
Россия, 1 pl. Akad. Kurchatova, Moscow, 123098
E. Severin
Russian Research Center for Molecular Diagnostics and Therapy
Email: e.severin@mail.ru
Россия, 8 Simferopol´skii b-r, Moscow, 117638
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