Enviar artigo por via de e-mail Effect of Nanosecond RF Pulses on Mitochondrial Membranes
- Autores: Zharkova L.P.1,2, Romanchenko I.V.1, Bol’shakov M.A.1,2, Rostov V.V.1
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Afiliações:
- Institute of High-Current Electronics of the Siberian Branch of the Russian Academy of Sciences
- National Research Tomsk State University
- Edição: Volume 60, Nº 8 (2017)
- Páginas: 1314-1318
- Seção: Article
- URL: https://bakhtiniada.ru/1064-8887/article/view/238563
- DOI: https://doi.org/10.1007/s11182-017-1214-4
- ID: 238563
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Resumo
Effect of nanosecond RF pulses on the state of isolated mitochondria and their membranes is investigated. Mitochondrial suspensions are exposed to periodic RF pulses with durations from 4 to 25 ns, frequencies from 0.6 to 1.0 GHz, amplitudes from 0.1 to 36 kV/cm, and pulse repetition frequencies 8–25 Hz. The integrity of the mitochondrial membranes is estimated from their resistance to electric current. The possibility of opening of protein pores with nonspecific permeability is determined from a change in the mitochondrial volume by registration of optical density of organelle suspension.
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Sobre autores
L. Zharkova
Institute of High-Current Electronics of the Siberian Branch of the Russian Academy of Sciences; National Research Tomsk State University
Autor responsável pela correspondência
Email: Zharkova_lubov@mail.ru
Rússia, Tomsk; Tomsk
I. Romanchenko
Institute of High-Current Electronics of the Siberian Branch of the Russian Academy of Sciences
Email: Zharkova_lubov@mail.ru
Rússia, Tomsk
M. Bol’shakov
Institute of High-Current Electronics of the Siberian Branch of the Russian Academy of Sciences; National Research Tomsk State University
Email: Zharkova_lubov@mail.ru
Rússia, Tomsk; Tomsk
V. Rostov
Institute of High-Current Electronics of the Siberian Branch of the Russian Academy of Sciences
Email: Zharkova_lubov@mail.ru
Rússia, Tomsk
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