DISTRIBUTION OF TWO-LOCUS HAPLOTYPES OF HLA-DRB1-TNFA-308 IN PATIENTS WITH ULCERATIVE COLITIS OF THE RUSSIAN POPULATION OF CHELYABINSK REGION
- Authors: Stashkevich D.S.1, Belyaeva S.V.1,2, Suslova T.A.1,2, Vasilenko A.G.3
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Affiliations:
- Chelyabinsk State University
- Chelyabinsk Blood Transfusion Station
- Chelyabinsk Regional Clinical Hospital
- Issue: Vol 20, No 3 (2017)
- Pages: 514-516
- Section: Articles
- URL: https://bakhtiniada.ru/1028-7221/article/view/119894
- ID: 119894
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Full Text
Abstract
The analysis of the distribution of HLA-DRB1-TNFA-308 two-locus haplotypes frequencies in patients with ulcerative colitis (UC) of the Russian population of the Chelyabinsk region is carried out in this article. The 19 haplotypes were identified, among which 4 haplotypes, containing -308*G TNFA allele, were characterized by high incidence rates in groups of UC patients and healthy individuals. A peculiarity of the UC patient group was the presence of two haplotypes containing the rare allele with the substitution -308*A TNFA: HLA DRB1* 01-TNFA-308*A; HLA DRB1* 13 -TNFA-308*A. These haplotypes were not found in the comparison group of healthy individuals. These haplotypes can be considered as markers of susceptibility to ulcerative colitis in the Russian Chelyabinsk region.
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About the authors
D. S. Stashkevich
Chelyabinsk State University
Author for correspondence.
Email: noemail@neicon.ru
Russian Federation
S. V. Belyaeva
Chelyabinsk State University; Chelyabinsk Blood Transfusion Station
Email: noemail@neicon.ru
Russian Federation
T. A. Suslova
Chelyabinsk State University; Chelyabinsk Blood Transfusion Station
Email: noemail@neicon.ru
Russian Federation
A. G. Vasilenko
Chelyabinsk Regional Clinical Hospital
Email: noemail@neicon.ru
Russian Federation
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