DISTRIBUTION OF TWO-LOCUS HAPLOTYPES OF HLA-DRB1-TNFA-308 IN PATIENTS WITH ULCERATIVE COLITIS OF THE RUSSIAN POPULATION OF CHELYABINSK REGION
- 作者: Stashkevich D.S.1, Belyaeva S.V.1,2, Suslova T.A.1,2, Vasilenko A.G.3
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隶属关系:
- Chelyabinsk State University
- Chelyabinsk Blood Transfusion Station
- Chelyabinsk Regional Clinical Hospital
- 期: 卷 20, 编号 3 (2017)
- 页面: 514-516
- 栏目: Articles
- URL: https://bakhtiniada.ru/1028-7221/article/view/119894
- ID: 119894
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详细
The analysis of the distribution of HLA-DRB1-TNFA-308 two-locus haplotypes frequencies in patients with ulcerative colitis (UC) of the Russian population of the Chelyabinsk region is carried out in this article. The 19 haplotypes were identified, among which 4 haplotypes, containing -308*G TNFA allele, were characterized by high incidence rates in groups of UC patients and healthy individuals. A peculiarity of the UC patient group was the presence of two haplotypes containing the rare allele with the substitution -308*A TNFA: HLA DRB1* 01-TNFA-308*A; HLA DRB1* 13 -TNFA-308*A. These haplotypes were not found in the comparison group of healthy individuals. These haplotypes can be considered as markers of susceptibility to ulcerative colitis in the Russian Chelyabinsk region.
作者简介
D. Stashkevich
Chelyabinsk State University
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Email: noemail@neicon.ru
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S. Belyaeva
Chelyabinsk State University; Chelyabinsk Blood Transfusion Station
Email: noemail@neicon.ru
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T. Suslova
Chelyabinsk State University; Chelyabinsk Blood Transfusion Station
Email: noemail@neicon.ru
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A. Vasilenko
Chelyabinsk Regional Clinical Hospital
Email: noemail@neicon.ru
俄罗斯联邦
参考
- Сташкевич Д. С. Распределение генов HLA-DQA1, DQB1 у больных неспецифическим язвенным колитом русской популяции Челябинской области / Д. С. Сташкевич, А. О. Складчикова, С. В. Беляева, Т. А. Суслова, А. Г. Василенко// Российский иммунологический журнал.- 2015.-T. 9(18), № 2.- С. 564-566.
- Bouzid D. Inflammatory bowel disease: susceptibility and disease heterogeneity revealed by human leukocyte antigen genotyping / D. Bouzid, A. Kammoun, A. Amouri et al. // Genetic testing and Molecular Biomarkers.-2012.- Vol.16(6).-P. 482-487.
- Excoffier L. Arlequin suite ver 3.5: a new series of programs to perform population genetics analyses under Linux and Windows / L. Excoffier, HE. Lis-cher // Molecular Ecology Resources.- 2010.- Vol. 10, Is. 3.- P. 564-567.
- Mohammadi M. Association of HLA-DRB 1 Alleles with Ulcerative Colitis in the City of Kerman, South Eastern Iran / M. Mohammadi, М. Rastin, H. Ra-fatpanah et al.// Iranian Journal of Allergy, Asthma and Immunology.- 2015.- 14(3).- P. 306-312.
- Tavares M. Tumour necrosis factor-alpha (-308G/ A) promoter polymorphism is associated with ulcerative colitis in Brazilian patients /M. Tavares, C. de Lima, W. Fernandes et al. // International journal of immunogenetics.- 2016.- Vol.43(6).-P. 376-382.
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