Iontophoretic transport of associates based on porous Keplerate-type cluster polyoxometalate Mo72Fe30 and containing biologically active substances


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Resumo

The possibility of iontophoretic transport through the native membranes of biologically active substances (vitamin B1 and insulin) associated with porous clusters Mo72Fe30 polyoxometalate of the Keplerate type is demonstrated for the first time in an experimental setup. The diffusion coefficient is estimated. The possibility of transferring Keplerate ions with a protective coating of biocompatible polymer polyvinylpyrrolidone is also shown.

Sobre autores

A. Ostroushko

Research Institute of Physics and Applied Mathematics

Autor responsável pela correspondência
Email: alexander.ostroushko@urfu.ru
Rússia, Yekaterinburg, 620002

I. Gagarin

Research Institute of Physics and Applied Mathematics

Email: alexander.ostroushko@urfu.ru
Rússia, Yekaterinburg, 620002

M. Tonkushina

Research Institute of Physics and Applied Mathematics

Email: alexander.ostroushko@urfu.ru
Rússia, Yekaterinburg, 620002

K. Grzhegorzhevskii

Research Institute of Physics and Applied Mathematics

Email: alexander.ostroushko@urfu.ru
Rússia, Yekaterinburg, 620002

I. Danilova

Research Institute of Physics and Applied Mathematics; Institute of Immunology and Physiology, Ural Branch

Email: alexander.ostroushko@urfu.ru
Rússia, Yekaterinburg, 620002; Yekaterinburg, 620049

I. Gette

Research Institute of Physics and Applied Mathematics; Institute of Immunology and Physiology, Ural Branch

Email: alexander.ostroushko@urfu.ru
Rússia, Yekaterinburg, 620002; Yekaterinburg, 620049

G. Kim

Postovsky Institute of Organic Synthesis, Ural Branch

Email: alexander.ostroushko@urfu.ru
Rússia, Yekaterinburg, 620990

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