Thermodynamics of sulfamethoxazole dissolution in organic solvents at 293.15–323.15 K

Resumo

The solubilities of the sulfonamide—sulfamethoxazole in methanol, ethanol, 1-propanol, 2-propanol, and chloroform have been determined at 293.15–323.15 K by a static equilibrium method. The experimental results can be approximated with Apelblat equation. The positive enthalpy Δ_solH and entropy Δ_solS for each system revealed that sulfamethoxazole dissolution in each solvent is an entropy-driven process.