Photosensitizing Activity of Steroid Derivatives of Pyropheophorbide in the Oxidation of Tryptophan in the Aqueous Phase


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Solubilization with pluronic F-127 gave water-soluble forms of hydrophobic photosensitizers—steroid derivatives of pyropheophorbide a. Solubilization was performed by evaporating the chloroform co-solutions of photosensitizer and pluronic (triple block copolymer of ethylene and propylene oxide) and subsequently dissolving the resulting dry residue in water. The concentration ratios of modified pyropheophorbide–pluronic at which the photosensitizer completely passed into the aqueous phase were determined. Among the starting hydrophobic photosensitizers, pyropheophorbide–dihydrotestosterone possessed the highest activity in photosensitized oxidation of anthracene with singlet oxygen in chloroform, while after solubilization, pyropheophorbide–testosterone was most active in the test (for photodynamic therapy) oxidation of tryptophan in aqueous solutions.

作者简介

A. Solov’eva

Semenov Institute of Chemical Physics, Russian Academy of Sciences

编辑信件的主要联系方式.
Email: anna@polymer.chph.ras.ru
俄罗斯联邦, Moscow, 119991

A. Kur’yanova

Semenov Institute of Chemical Physics, Russian Academy of Sciences

Email: anna@polymer.chph.ras.ru
俄罗斯联邦, Moscow, 119991

M. Savko

Semenov Institute of Chemical Physics, Russian Academy of Sciences

Email: anna@polymer.chph.ras.ru
俄罗斯联邦, Moscow, 119991

N. Aksenova

Semenov Institute of Chemical Physics, Russian Academy of Sciences; Institute of Regenerative Medicine, Sechenov First Moscow State Medical University

Email: anna@polymer.chph.ras.ru
俄罗斯联邦, Moscow, 119991; Moscow, 119991

E. Afanas’evskaya

Institute of Regenerative Medicine, Sechenov First Moscow State Medical University

Email: anna@polymer.chph.ras.ru
俄罗斯联邦, Moscow, 119991

V. Zolottsev

Orekhovich Research Institute of Biomedical Chemistry, Russian Academy of Sciences

Email: anna@polymer.chph.ras.ru
俄罗斯联邦, Moscow

M. Taratynova

Orekhovich Research Institute of Biomedical Chemistry, Russian Academy of Sciences

Email: anna@polymer.chph.ras.ru
俄罗斯联邦, Moscow

G. Ponomarev

Orekhovich Research Institute of Biomedical Chemistry, Russian Academy of Sciences

Email: anna@polymer.chph.ras.ru
俄罗斯联邦, Moscow

P. Timashev

Institute of Regenerative Medicine, Sechenov First Moscow State Medical University; Crystallography and Photonics Federal Research Center, Russian Academy of Sciences

Email: anna@polymer.chph.ras.ru
俄罗斯联邦, Moscow, 119991; Moscow

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