Interaction between super-reduced cobalamin and selenite


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Abstract

The kinetics of the reaction between the two-electron reduced form of cobalamin (super-reduced cobalamin, cob(I)alamin, or Cbl(I)) and sodium selenite in an alkaline medium is studied spectrophotometrically. It is shown that the selenite rapidly oxidizes Cbl(I) to cob(II)alamin (Cbl(II)). It is established that the active form of the oxidant is the protonated selenite anion (HSeO3-), which receives six electrons during the reaction and transforms into HSe. The reactions of cob(I)alamin oxidation by selenite and sulfite are compared.

About the authors

I. A. Dereven’kov

Ivanovo State University of Chemistry and Technology

Author for correspondence.
Email: derevenkov@gmail.com
Russian Federation, Ivanovo, 153000

D. S. Salnikov

Ivanovo State University of Chemistry and Technology

Email: derevenkov@gmail.com
Russian Federation, Ivanovo, 153000

S. V. Makarov

Ivanovo State University of Chemistry and Technology

Email: derevenkov@gmail.com
Russian Federation, Ivanovo, 153000

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