Thermodynamic parameters analysis of ethidium bromide and mitoxantrone binding with DNA by adsorption isotherms
- 作者: Vardevanyan P.O.1, Parsadanyan M.A.1, Antonyan A.P.1, Hakobyan S.N.2
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隶属关系:
- Yerevan State University, Faculty of Biology
- State Engineering University of Armenia
- 期: 卷 91, 编号 6 (2017)
- 页面: 1143-1145
- 栏目: Short Communications
- URL: https://bakhtiniada.ru/0036-0244/article/view/169562
- DOI: https://doi.org/10.1134/S0036024417060280
- ID: 169562
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详细
Analysis of the adsorption isotherms by virtue of experimentally obtained data of anti-tumorous compound mitoxantrone and ethidium bromide binding with DNA has been carried out. The obtained data showed that throughout the comparatively simple linear isotherm, the more precise values of the binding constant K and number of nucleotides n, per binding site were received. Based on the values of K, those for the enthalpy changes at complex-formation of these ligands with DNA were obtained.
作者简介
P. Vardevanyan
Yerevan State University, Faculty of Biology
编辑信件的主要联系方式.
Email: p.vardevanyan@ysu.am
亚美尼亚, Yerevan
M. Parsadanyan
Yerevan State University, Faculty of Biology
Email: p.vardevanyan@ysu.am
亚美尼亚, Yerevan
A. Antonyan
Yerevan State University, Faculty of Biology
Email: p.vardevanyan@ysu.am
亚美尼亚, Yerevan
S. Hakobyan
State Engineering University of Armenia
Email: p.vardevanyan@ysu.am
亚美尼亚, Yerevan
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