Thermodynamic parameters analysis of ethidium bromide and mitoxantrone binding with DNA by adsorption isotherms


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Analysis of the adsorption isotherms by virtue of experimentally obtained data of anti-tumorous compound mitoxantrone and ethidium bromide binding with DNA has been carried out. The obtained data showed that throughout the comparatively simple linear isotherm, the more precise values of the binding constant K and number of nucleotides n, per binding site were received. Based on the values of K, those for the enthalpy changes at complex-formation of these ligands with DNA were obtained.

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P. Vardevanyan

Yerevan State University, Faculty of Biology

编辑信件的主要联系方式.
Email: p.vardevanyan@ysu.am
亚美尼亚, Yerevan

M. Parsadanyan

Yerevan State University, Faculty of Biology

Email: p.vardevanyan@ysu.am
亚美尼亚, Yerevan

A. Antonyan

Yerevan State University, Faculty of Biology

Email: p.vardevanyan@ysu.am
亚美尼亚, Yerevan

S. Hakobyan

State Engineering University of Armenia

Email: p.vardevanyan@ysu.am
亚美尼亚, Yerevan

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