Effect of medium acidity on the thermodynamics and kinetics of the reaction of pyridoxal 5′-phosphate with isoniazid in an aqueous solution


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Аннотация

Thermodynamic characteristics of the formation of the Schiff base between isoniazid and pyridoxal 5'-phosphate in an aqueous solution at different pH values of a medium are determined by means of spectrophotometry and calorimetric titration. The process kinetics is studied spectrophotometrically, and the reaction rate constants for the formation of the imine at different acidities of a medium are determined. Biochemical aspects of the binding of pyridoxal 5'-phosphate into stable compounds are discussed.

Авторлар туралы

G. Gamov

Ivanovo State University of Chemistry and Technology

Хат алмасуға жауапты Автор.
Email: georgegamov38@gmail.com
Ресей, Ivanovo, 153000

M. Zavalishin

Ivanovo State University of Chemistry and Technology

Email: georgegamov38@gmail.com
Ресей, Ivanovo, 153000

T. Usacheva

Ivanovo State University of Chemistry and Technology

Email: georgegamov38@gmail.com
Ресей, Ivanovo, 153000

V. Sharnin

Ivanovo State University of Chemistry and Technology; Krestov Institute of Solution Chemistry

Email: georgegamov38@gmail.com
Ресей, Ivanovo, 153000; Ivanovo, 153045

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