Modifying the collagen framework of costal cartilage under the impact of UV and a flavin mononucleotide
- Authors: Ignat’eva N.Y.1,2, Zakharkina O.L.2, Semchishen V.A.2, Molchanov M.D.1, Lunin V.V.1, Bagratashvili V.N.1,2
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Affiliations:
- Department of Chemistry
- Institute on Laser and Information Technologies
- Issue: Vol 90, No 3 (2016)
- Pages: 683-687
- Section: Photochemistry and Magnetochemistry
- URL: https://bakhtiniada.ru/0036-0244/article/view/167960
- DOI: https://doi.org/10.1134/S0036024416030171
- ID: 167960
Cite item
Abstract
Modifications of the matrix of the tissue of costal cartilage under the impact of UV (λ = 365 nm) and a flavin mononucleotide (FMN) is studied. The changes in the macroscopic properties of the tissue are detected by means of differential scanning calorimetry and under the conditions of uniaxial compression during mechanical testing. The endothermic effects of the denaturation of the collagen framework of the tissue and the Young’s modulus are determined. It is shown that the presence of a flavin mononucleotide in the interstitial fluid leads lowers the temperature of collagen denaturation by 2.5°С and doubles the Young’s modulus. It is found that the temperature of denaturation and the Young’s modulus grow gradually after treating the tissue with the UV radiation, and their values ultimately exceed by far the corresponding values for intact samples. It is concluded that the obtained data indicate the possibility of stabilizing the framework of the matrix of costal cartilage under the impact of UV radiation and a flavin mononucleotide.
About the authors
N. Yu. Ignat’eva
Department of Chemistry; Institute on Laser and Information Technologies
Author for correspondence.
Email: nyu@kge.msu.ru
Russian Federation, Moscow, 119991; Moscow, 140700
O. L. Zakharkina
Institute on Laser and Information Technologies
Email: nyu@kge.msu.ru
Russian Federation, Moscow, 140700
V. A. Semchishen
Institute on Laser and Information Technologies
Email: nyu@kge.msu.ru
Russian Federation, Moscow, 140700
M. D. Molchanov
Department of Chemistry
Email: nyu@kge.msu.ru
Russian Federation, Moscow, 119991
V. V. Lunin
Department of Chemistry
Email: nyu@kge.msu.ru
Russian Federation, Moscow, 119991
V. N. Bagratashvili
Department of Chemistry; Institute on Laser and Information Technologies
Email: nyu@kge.msu.ru
Russian Federation, Moscow, 119991; Moscow, 140700
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