Study on the Solubility of Ketoprofen From Solid Dispersions with Polyvinylpyrrolidone

Abstract

The solubility of ketoprofen (nonsteroidal anti-inflammatory drug) from solid dispersions based on polyvinylpyrrolidone (PVP-10000, PVP-12600 and PVP-24000) is studied. The use of solid dispersions (SDs) increases the solubility and dissolution rate. The solubility of ketoprofen from SD increases by 1.5–2.6 times. The rate of dissolution from SDs increases by 1.5–3.2 times. The studies conducted by a complex of physical and chemical methods suggest that an improved release of ketoprofen from SDs is due to the generation of solid solution of the active substance in the polymer, the formation of intermolecular hydrogen bonds of the active substance with polyvinylpyrrolidone and the solubilizing effect of the polymer during the dissolution of ketoprofen. The results obtained can be used in the development of fast-dissolving solid dosage forms of ketoprofen with enhanced bioavailability.