Email this article Flow Cytometry Analysis of G0/G1 Diploid Cell Fraction in Ovarian Cancer Tissue
- Authors: Bogush T.A.1, Mamichev I.A.1, Borisenko I.P.2, Bogush E.A.1, Vichljantseva N.O.1, Kirsanov V.J.3
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Affiliations:
- Blokhin National Medical Research Center of Oncology
- Department of Fundamental Medicine
- Sechenov First Medical University
- Issue: Vol 73, No 5 (2018)
- Pages: 244-247
- Section: Article
- URL: https://bakhtiniada.ru/0027-1314/article/view/163747
- DOI: https://doi.org/10.3103/S0027131418050024
- ID: 163747
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Abstract
The proportion of diploid cells in the G0/G1 cell cycle phases was estimated by flow cytometry in 60 samples of stage III serous ovarian cancer tissue. The tumor tissue shows considerable heterogeneity with regard to the content of this tissue fraction, which ranged from 27 to 95% with a median of 73%. Statistically significant differences in the size of this fraction were identified by comparing tumor subgroups sensitive and resistant to first-line platinum-taxane chemotherapy. Predictive significance of the G0/G1 fraction was concluded and quantitative evaluation of this fraction is recommended for clinical use.
About the authors
T. A. Bogush
Blokhin National Medical Research Center of Oncology
Author for correspondence.
Email: tatbogush@mail.ru
Russian Federation, Moscow, 115478
I. A. Mamichev
Blokhin National Medical Research Center of Oncology
Email: tatbogush@mail.ru
Russian Federation, Moscow, 115478
Iu. P. Borisenko
Department of Fundamental Medicine
Email: tatbogush@mail.ru
Russian Federation, Moscow, 119991
E. A. Bogush
Blokhin National Medical Research Center of Oncology
Email: tatbogush@mail.ru
Russian Federation, Moscow, 115478
N. O. Vichljantseva
Blokhin National Medical Research Center of Oncology
Email: tatbogush@mail.ru
Russian Federation, Moscow, 115478
V. Ju. Kirsanov
Sechenov First Medical University
Email: tatbogush@mail.ru
Russian Federation, Moscow, 119991
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