Flow Cytometry Analysis of G0/G1 Diploid Cell Fraction in Ovarian Cancer Tissue
- Авторы: Bogush T.A.1, Mamichev I.A.1, Borisenko I.P.2, Bogush E.A.1, Vichljantseva N.O.1, Kirsanov V.J.3
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Учреждения:
- Blokhin National Medical Research Center of Oncology
- Department of Fundamental Medicine
- Sechenov First Medical University
- Выпуск: Том 73, № 5 (2018)
- Страницы: 244-247
- Раздел: Article
- URL: https://bakhtiniada.ru/0027-1314/article/view/163747
- DOI: https://doi.org/10.3103/S0027131418050024
- ID: 163747
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Аннотация
The proportion of diploid cells in the G0/G1 cell cycle phases was estimated by flow cytometry in 60 samples of stage III serous ovarian cancer tissue. The tumor tissue shows considerable heterogeneity with regard to the content of this tissue fraction, which ranged from 27 to 95% with a median of 73%. Statistically significant differences in the size of this fraction were identified by comparing tumor subgroups sensitive and resistant to first-line platinum-taxane chemotherapy. Predictive significance of the G0/G1 fraction was concluded and quantitative evaluation of this fraction is recommended for clinical use.
Об авторах
T. Bogush
Blokhin National Medical Research Center of Oncology
Автор, ответственный за переписку.
Email: tatbogush@mail.ru
Россия, Moscow, 115478
I. Mamichev
Blokhin National Medical Research Center of Oncology
Email: tatbogush@mail.ru
Россия, Moscow, 115478
Iu. Borisenko
Department of Fundamental Medicine
Email: tatbogush@mail.ru
Россия, Moscow, 119991
E. Bogush
Blokhin National Medical Research Center of Oncology
Email: tatbogush@mail.ru
Россия, Moscow, 115478
N. Vichljantseva
Blokhin National Medical Research Center of Oncology
Email: tatbogush@mail.ru
Россия, Moscow, 115478
V. Kirsanov
Sechenov First Medical University
Email: tatbogush@mail.ru
Россия, Moscow, 119991
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