Cryochemical modification of drugs: Nanosized form III piroxicam and its physical and chemical properties

Abstract

Dynamic sublimation in a stream of heated carrier gas and low-temperature condensation are used to perform structural and dimensional modification of nonsteroidal anti-inflammatory preparation of 4-hydroxy-2-methyl-N-(2-pyridinyl)-2Н-1,2-benzothiazin-3-carboxamide 1,1-dioxide (piroxicam) and to obtain its nanoscale form. Thus obtained samples correspond to the known thermodynamically metastable Form III of the compound. The average particle size of the preparation is d_av = 300 ± 30 nm. The resulting nanosized form of piroxicam is relatively stable with respect to structural and dimensional transformations for at least four years.