Morphological and physiological properties of the micromycete Arthrobotrys longa, a producer of longolytin, a proteolytic complex with a thrombolytic effect


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Abstract

Production of proteinases with plasmin-like and plasminogen-activating activities by a micromycete Arthrobotrys longa 1 was studied. Polycyclic growth of the producer in submerged cultures was observed, with an endogenous rhythm of periods of intense microconidia formation alternating with the phases of drastic increase in the content of producing mycelium. The highest plasmin-like and plasminogen-activating activities (up to 1000 and 500 cond. U/mL, respectively) were found to correlate with the polycyclic growth of the producer, coinciding with the stage of microconidia germination. Enhanced secretion of proteinases with plasmin-like and plasminogen-activating activity was found to be associated with increased specific growth rate of А. longa 1.

About the authors

T. S. Sharkova

Faculty of Biology

Email: aosmol@mail.ru
Russian Federation, Moscow

E. I. Kornienko

Faculty of Biology

Email: aosmol@mail.ru
Russian Federation, Moscow

A. A. Osmolovskii

Faculty of Biology

Author for correspondence.
Email: aosmol@mail.ru
Russian Federation, Moscow

V. G. Kreier

Faculty of Biology

Email: aosmol@mail.ru
Russian Federation, Moscow

N. A. Baranova

Faculty of Biology

Email: aosmol@mail.ru
Russian Federation, Moscow

N. S. Egorov

International Biotechnological Center

Email: aosmol@mail.ru
Russian Federation, Moscow

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