Morphological and physiological properties of the micromycete Arthrobotrys longa, a producer of longolytin, a proteolytic complex with a thrombolytic effect
- Authors: Sharkova T.S.1, Kornienko E.I.1, Osmolovskii A.A.1, Kreier V.G.1, Baranova N.A.1, Egorov N.S.2
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Affiliations:
- Faculty of Biology
- International Biotechnological Center
- Issue: Vol 85, No 2 (2016)
- Pages: 180-184
- Section: Experimental Articles
- URL: https://bakhtiniada.ru/0026-2617/article/view/162538
- DOI: https://doi.org/10.1134/S0026261716020168
- ID: 162538
Cite item
Abstract
Production of proteinases with plasmin-like and plasminogen-activating activities by a micromycete Arthrobotrys longa 1 was studied. Polycyclic growth of the producer in submerged cultures was observed, with an endogenous rhythm of periods of intense microconidia formation alternating with the phases of drastic increase in the content of producing mycelium. The highest plasmin-like and plasminogen-activating activities (up to 1000 and 500 cond. U/mL, respectively) were found to correlate with the polycyclic growth of the producer, coinciding with the stage of microconidia germination. Enhanced secretion of proteinases with plasmin-like and plasminogen-activating activity was found to be associated with increased specific growth rate of А. longa 1.
About the authors
T. S. Sharkova
Faculty of Biology
Email: aosmol@mail.ru
Russian Federation, Moscow
E. I. Kornienko
Faculty of Biology
Email: aosmol@mail.ru
Russian Federation, Moscow
A. A. Osmolovskii
Faculty of Biology
Author for correspondence.
Email: aosmol@mail.ru
Russian Federation, Moscow
V. G. Kreier
Faculty of Biology
Email: aosmol@mail.ru
Russian Federation, Moscow
N. A. Baranova
Faculty of Biology
Email: aosmol@mail.ru
Russian Federation, Moscow
N. S. Egorov
International Biotechnological Center
Email: aosmol@mail.ru
Russian Federation, Moscow
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