Structure, DNA bonding, and biological activity of a novel Pb(II) complex of 1,1-bis(5-(pyrazin-2-yl)-1,2,4-triazol-3-yl) methane


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A novel complex [Pb(bptm)(NO3)(H2O)2] (bptm = 1,1-bis(5-(pyrazin-2-yl)-1,2,4-triazol-3-yl) methane) is synthesized and characterized by IR spectroscopy and single crystal X-ray diffraction. Its reactivity with calf thymus DNA and HeLa cell DNA is measured using UV absorption and fluorescence spectroscopies. Gel electrophoresis assay demonstrates the ability of the complex to cleave pBR322 plasmid DNA. Eventually, the complex can suitably dock with a special DNA.

作者简介

E.-J. Gao

Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry

Email: mczhu@syuct.edu.cn
中国, Shenyang

B. Meng

Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry

Email: mczhu@syuct.edu.cn
中国, Shenyang

J.-Q. Su

Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry

Email: mczhu@syuct.edu.cn
中国, Shenyang

T.-T. Peng

Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry

Email: mczhu@syuct.edu.cn
中国, Shenyang

Z.-Z. Qi

Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry

Email: mczhu@syuct.edu.cn
中国, Shenyang

B. Jia

Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry

Email: mczhu@syuct.edu.cn
中国, Shenyang

Y.-H. Feng

Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry

Email: mczhu@syuct.edu.cn
中国, Shenyang

M.-C. Zhu

Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry

编辑信件的主要联系方式.
Email: mczhu@syuct.edu.cn
中国, Shenyang

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