Enviar artigo por via de e-mail Structure, DNA bonding, and biological activity of a novel Pb(II) complex of 1,1-bis(5-(pyrazin-2-yl)-1,2,4-triazol-3-yl) methane
- Autores: Gao E.1, Meng B.1, Su J.1, Peng T.1, Qi Z.1, Jia B.1, Feng Y.1, Zhu M.1
-
Afiliações:
- Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry
- Edição: Volume 58, Nº 8 (2017)
- Páginas: 1560-1566
- Seção: Article
- URL: https://bakhtiniada.ru/0022-4766/article/view/161706
- DOI: https://doi.org/10.1134/S0022476617080121
- ID: 161706
Citar
Acesso aberto
Acesso está concedido
Somente assinantes
Resumo
A novel complex [Pb(bptm)(NO3)(H2O)2] (bptm = 1,1-bis(5-(pyrazin-2-yl)-1,2,4-triazol-3-yl) methane) is synthesized and characterized by IR spectroscopy and single crystal X-ray diffraction. Its reactivity with calf thymus DNA and HeLa cell DNA is measured using UV absorption and fluorescence spectroscopies. Gel electrophoresis assay demonstrates the ability of the complex to cleave pBR322 plasmid DNA. Eventually, the complex can suitably dock with a special DNA.
Palavras-chave
Sobre autores
E.-J. Gao
Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry
Email: mczhu@syuct.edu.cn
República Popular da China, Shenyang
B. Meng
Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry
Email: mczhu@syuct.edu.cn
República Popular da China, Shenyang
J.-Q. Su
Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry
Email: mczhu@syuct.edu.cn
República Popular da China, Shenyang
T.-T. Peng
Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry
Email: mczhu@syuct.edu.cn
República Popular da China, Shenyang
Z.-Z. Qi
Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry
Email: mczhu@syuct.edu.cn
República Popular da China, Shenyang
B. Jia
Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry
Email: mczhu@syuct.edu.cn
República Popular da China, Shenyang
Y.-H. Feng
Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry
Email: mczhu@syuct.edu.cn
República Popular da China, Shenyang
M.-C. Zhu
Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry
Autor responsável pela correspondência
Email: mczhu@syuct.edu.cn
República Popular da China, Shenyang
Arquivos suplementares
