2-methylpyridinium 5-(2,4-dinitrophenyl)-6-oxo-2-thioxo-1,2,3,6-tetrahydropyrimidin-4-olate: Synthesis, crystal structure, and biological evaluation


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The titled complex is synthesized from the ethanolic solutions of 1-chloro-2,4-dinitrobenzene, 2-thiobarbituric acid, and 2-methylpyridine and characterized by spectral and elemental analyses. The single crystal X-ray diffraction results for the complex are compatible with the spectral observations. The titled complex exhibits anticonvulsant activity and reduces all phases of convulsion even at a low dosage. Acute toxicity studies of the complex are performed to understand the safer dose concentration for clinical trials.

作者简介

G. Mangaiyarkarasi

PG and Research Department of Chemistry

Email: kalaivbalaj@yahoo.co.in
印度, Tamil Nadu

G. Sridevi

PG and Research Department of Chemistry

Email: kalaivbalaj@yahoo.co.in
印度, Tamil Nadu

P. Poornima Devi

PG and Research Department of Chemistry

Email: kalaivbalaj@yahoo.co.in
印度, Tamil Nadu

D. Kalaivani

PG and Research Department of Chemistry

编辑信件的主要联系方式.
Email: kalaivbalaj@yahoo.co.in
印度, Tamil Nadu

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