Genetic Approaches in Pluripotent Stem Cell Studies and Practical Applications

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The discovery of pluripotent stem cells (PSCs) had a tremendous impact in various areas of biology, while the application of genetic approaches to these cells further expanded the repertoire of both fundamental and applied tasks addressed with the help of PSCs. For example, mouse embryonic stem cells (ESCs) have served as an indispensable tool in functional genetics, which allowed to define biological role of thousands of mouse genes using gene knockout tecniques. Subsequent discovery of human ESCs opened bond perspectives in tissue replacement therapy, while the discovery of induced pluripotent stem cells (iPSCs), which eliminated several technical, immunological, and ethical issues associated with the derivation and clinical use of ESCs, has made the perspectives even closer. The manuscript overviews some of genetic approaches that, in combination with PSC technologies, can provide a new level of solution to a wide range of biomedical tasks.

Sobre autores

A. Kuzmin

Institute of Cytology of the Russian Academy of Sciences

St. Petersburg, Russia

S. Sinenko

Institute of Cytology of the Russian Academy of Sciences

St. Petersburg, Russia

E. Bakhmet

Institute of Cytology of the Russian Academy of Sciences

St. Petersburg, Russia

A. Fotina

Institute of Cytology of the Russian Academy of Sciences

St. Petersburg, ussia

V. Ermakova

Institute of Cytology of the Russian Academy of Sciences

St. Petersburg, Russia

A. Tomilin

Institute of Cytology of the Russian Academy of Sciences

Email: a.tomilin@incras.ru
St. Petersburg, Russia

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