The vesicular seminal secretion diagnostic value at chronic prostatitis in case of experimental research on the small laboratory animals

The aim of the study: to clarify the diagnostic value of the seminal vesicles mucus in chronic prostatitis using an experiment in small laboratory animals. Material and methods. The research was carried out on 98 not purebred white male rats in two series of experiments (acute and chronic prostatitis — 46 and 52 rats respectively). In both series rats were divided into four groups. In the 1st group there were intact rats (controls). The 2nd group rats received 0,25 ml of dymexide through rectum. The 3rd group rats received 0,25 ml of turpentine same administration. The 4th group rats received 1 ml of the mix of turpentine and dymexide through rectum. The nature and characteristics of macro- and microscopic changes in the prostate in acute and chronic prostatitis were analyzed (in 10 and 35 days from the beginning respectively). Results. In 10 days a clear inflammatory process was seen in the prostates of 3rd and 4th group rats. It was accompanied by acute inflammation of the seminal vesicles, which was confirmed by their increase and seal. The analysis of weight factor indicators of the prostate and seminal vesicles showed its increase in 3rd and 4th groups in comparison with corresponding factors in 1st and 2nd groups. In 35 days from the beginning of the experiment these factors became significantly higher in 3rd and 4th groups comparing with the controls. Histological examination of the prostate and seminal vesicles showed signs of chronic inflammation (in 80 and 57% respectively) in 3rd and 4th group rats. Mucus stretch between the jaws of tweezers increased to a level, which was 5 times higher than normal (controls) in seminal vesicles chronic inflammation. Conclusion. The sign, indirectly indicating the presence of inflammation in the seminal vesicles in this experiment can be regarded as an increase in the size of the seminal vesicles, increased mucus stretch between the jaws of tweezers as well as an increase in weight factor indicators. The basis for this conclusion has served as a direct dependence of the frequency of the above symptoms occurrence with evidence to confirm the presence of inflammation obtained by morphological study.

chronic prostatitis, experimental study, model, seminal vesicles, mucus, diagnostics