Email this article Selected aspects of the epidemiology of tumors and tumor-like diseases of the spine and spinal cord in children: A 19-year regional cohort study in the Leningrad region
- Authors: Snishuk V.P.1,2, Vladovskaya M.D.3, Vissarionov S.V.1, Krutelev N.A.1,2, Kaminskiy A.V.2, Petrova I.S.1
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Affiliations:
- The Turner Scientific Research Institute for Children’s Orthopedics
- Leningrad Region Children’s Hospital
- First State Pavlov Medical University of Saint Petersburg, R. Gorbacheva Memorial Research Institute for Pediatric Oncology, Hematology and Transplantation
- Issue: Vol 6, No 2 (2018)
- Pages: 44-53
- Section: Original papers
- URL: https://bakhtiniada.ru/turner/article/view/8989
- DOI: https://doi.org/10.17816/PTORS6244-53
- ID: 8989
Cite item
Abstract
Background. Statistical analysis of spinal tumors in children is difficult because of its rarity and different morphology. Benign tumor and tumor-like processes are not included in modern oncology literature even though intracanal tumors have the most severe prognosis and influence on a patient’s quality of life.
Aim. To evaluate the incidence, epidemiological structure (anatomical, sex, morphological structure), clinical characteristics, and survival of pediatric patients with tumors and tumor-like diseases of the spine and spinal cord in a single region of Russia.
Materials and methods. The data of 110 children with tumors and tumor-like diseases of the spine and spinal cord from the Leningrad region who received surgical treatment in Leningrad regional children's hospitals between 1998 and 2016 were included in the study. The authors evaluated the incidence, mortality, and survival rates adjusted for age, sex, morphology, and primary site of growth.
Results. The average annual morbidities of pediatric spinal tumors (including the spine and spinal canal) in the Leningradsaya oblast region from 1998 to 2016 were 1.93 per 100 000 pediatric patients and 0.3 per 100 000 for neuro-epithelial tumors of the spinal cord. The mortality rate was 0.2 per 100 000 pediatric patients. Spinal cord tumors of the cranio-vertebral and cervical zones as intramedullary low-malignant and extramedullary malignant metastatic spinal tumors had a negative effect on survival.
Conclusions. The Leningrad regional data were generally comparable with the cancer registry data of other countries. The data suggest that pediatric spinal cord patients should be treated in regional neurosurgical pediatric clinics.
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##article.viewOnOriginalSite##About the authors
Viktor P. Snishuk
The Turner Scientific Research Institute for Children’s Orthopedics; Leningrad Region Children’s Hospital
Author for correspondence.
Email: v_p_s@list.ru
MD, Neurosurgeon
Russian Federation, 64, Parkovaya str., Saint-Petersburg, Pushkin, 196603; Saint-PetersburgMaria D. Vladovskaya
First State Pavlov Medical University of Saint Petersburg, R. Gorbacheva Memorial Research Institute for Pediatric Oncology, Hematology and Transplantation
Email: marydeton@mail.ru
MD, PhD, Hematologist, Oncologist
Russian Federation, Saint PetersburgSergey V. Vissarionov
The Turner Scientific Research Institute for Children’s Orthopedics
Email: turner01@mail.ru
ORCID iD: 0000-0003-4235-5048
MD, PhD, Professor, Deputy Director for research and academic affairs, Head of the Department of Spinal Pathology and Neurosurgery
Russian Federation, 64, Parkovaya str., Saint-Petersburg, Pushkin, 196603Nikolay A. Krutelev
The Turner Scientific Research Institute for Children’s Orthopedics; Leningrad Region Children’s Hospital
Email: n.krutelev@mail.ru
MD, Neurosurgeon
Russian Federation, 64, Parkovaya str., Saint-Petersburg, Pushkin, 196603; Saint-PetersburgAlexander V. Kaminskiy
Leningrad Region Children’s Hospital
Email: kamin_al@mail.ru
MD, Neurosurgeon
Russian Federation, Saint-PetersburgIrina S. Petrova
The Turner Scientific Research Institute for Children’s Orthopedics
Email: iskorchagina@gmail.ru
MD, Neurosurgeon
Russian Federation, 64, Parkovaya str., Saint-Petersburg, Pushkin, 196603References
- Белогурова М.Б., Владовская М.Д., Коршунов Н.Б., и др. Эпидемиология опухолей центральной нервной системы у детей за период 1989–1999 гг. // Вопросы гематологии/онкологии и иммунопатологии в педиатрии. – 2002. – Т. 1. – № 1. – С. 35–38. [Belogurova MB, VIadovskaya MD, Korshunov NB, et al. Epidemiology of central nervous system tumours in children in St. Petersburg over 1989-1999. Pediatric Haematology/Oncology and Immunopathology. 2002;1(1):35-38. (In Russ.)]
- Мушкин А.Ю., Мальченко О.В. Онкологическая вертебрология: избранные вопросы. – Новосибирск, 2012. [Mushkin AY, Mal’chenko OV. Oncological vertebrology: selected questions. Novosibirsk; 2012. (In Russ.)]
- Gurney JG, Wall DA, Jukich PJ, Davis FG. The contribution of nonmalignant tumors to CNS tumor incidence rates among children in the United States. Cancer Causes Control. 1999;10(2):101-105. doi: 10.1023/A:1008867024545.
- Gurney JG, Smith MA, Bunin GR. CNS and Miscellaneous Intracranial and Intraspinal Neoplasms. In: Cancer Incidence and Survival among Children and Adolescents: United States SEER Program 1975-1995. Ed by L.A.G. Ries, M.A. Smith, J.G. Gurney, et al. Bethesda: National Cancer Institute; 1999. P. 51-63.
- Heideman RL, Packer RJ, Albright LA, et al. Tumors of the central nervous system. In: Principles and Practices of Pediatric Oncology. Ed by P. Pizzo, D. Poplack. 3rd ed. Philadelphia, PA: Lippincott-Raven; 1997. P. 633-697.
- Kramer K, Kushner B, Heller G, Cheung N-KV. Neuroblastoma metastatic to the central nervous system. Cancer. 2001;91(8):1510-1519. doi: 10.1002/1097-0142(20010415)91:8<1510::aid-cncr1159>3.0.co;2-i.
- Farinotti M, Ferrarini M, Solari A, Filippini G. Incidence and survival of childhood CNS tumours in the Region of Lombardy, Italy. Brain. 1998;121(8):1429-1436. doi: 10.1093/brain/121.8.1429.
- Kaatsch P, Rickert CH, Kühl J, et al. Population-based epidemiologic data on brain tumors in Germa children. Cancer. 2001;92(12):3155-3164. doi: 10.1002/1097-0142(20011215)92:12<3155::aid-cncr10158>3.0.co;2-c.
- Smith MA, Freidlin B, Gloeckler Ries LA, Simon R. Trends in Reported Incidence of Primary Malignant Brain Tumors in Children in the United States. J Natl Cancer Inst. 1998;90(17):1269-1277. doi: 10.1093/jnci/90.17.1269.
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