Practical issues in the use of emollients containing filaggrin modulators in the management of patients with atopic dermatitis and xerosis: Resolution of the Expert board

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Leading experts in the field of dermatovenereology, cosmetology, and allergology took part in the meeting of the expert board. Following the discussion, the working groups of the Expert board assessed the role of filaggrin deficiency in the pathogenesis of atopic dermatitis and other diseases/conditions accompanied by xerosis. In addition, they formed recommendations for the use of emollient Admera, taking into account the role of filaggrin in the development of atopic dermatitis and xerosis. The experts comprehensively analyzed the best basic therapy for atopic dermatitis, xerosis of diverse etiologies secondary preventive options for atopic dermatitis and developed unified recommendations on the principles of managing such patients. In addition, they also established the place of emollients in clinical practice. Additional educational, informational, and organizational
activities were proposed to help patients and doctors understand the problem of using emollients in atopic dermatitis and xerosis of diverse etiologies.

This article was first published in the Kremlin Medicine Journal (Kruglova LS, Lvov AN, Araviyskaya ER, et al. Practical issues on the application of emollients containing filaggrin modulators in the management of patients with atopic dermatitis and xerosis. Resolution of the Council of experts. Kremlin Medicine Journal. 2022;1:87–94. doi: 10.26269/m4bj-f167). This article published with permission from authors and copyright holder.

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Elena R. Araviyskaya

Academician I.P. Pavlov First St. Petersburg State Medical University

Email: arelenar@mail.ru
ORCID iD: 0000-0002-6378-8582
SPIN-code: 9094-9688

MD, MD, Dr. Sci. (Med.), Professor

Russian Federation, Saint Petersburg

Andrey L. Bakulev

Central State Medical Academy of Department of Presidential Affairs

Email: al_ba05@mail.ru
ORCID iD: 0000-0002-1450-4942
SPIN-code: 6708-7386

MD; Dr. Sci. (Med.), Professor

Russian Federation, Moscow

Aida G. Gadzhigoroeva

Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology

Email: aida2010@mail.ru
ORCID iD: 0000-0003-0489-0576

MD, Dr. Sci. (Med.), Professor

Russian Federation, Moscow

Olga G. Elisyutina

National Research Center — Institute of Immunology Federal Medical-Biological Agency of Russia

Author for correspondence.
Email: el-olga@yandex.ru
ORCID iD: 0000-0002-4609-2591
SPIN-code: 9567-1894

MD, Dr. Sci. (Med.)

Russian Federation, 24, Kashirskoyw shosse, Moscow, 115522

Rizida M. Zagrtdinova

Izhevsk State Medical Academy

Email: kafedra.derma@yandex.ru
ORCID iD: 0000-0003-0565-9149

MD, Dr. Sci. (Med.), Professor

Russian Federation, Izhevsk

Denis V. Zaslavsky

Saint-Petersburg State Pediatric Medical University

Email: venerology@gmail.com
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SPIN-code: 5832-9510

MD, Dr. Sci. (Med.), Professor

Russian Federation, Saint Petersburg

Oleg R. Ziganshin

South-Ural State Medical University

Email: ziganshin_oleg@mail.ru
ORCID iD: 0000-0002-5857-0319
SPIN-code: 5339-2533

MD, Dr. Sci. (Med.), Professor

Russian Federation, Chelyabinsk

Andrey V. Ignatovsky

Saint-Petersburg State University

Email: derm@list.ru
ORCID iD: 0000-0003-3048-2488
SPIN-code: 8500-0451

MD, Cand. Sci. (Med.), Assistant Professor

Russian Federation, Saint Petersburg

Muza M. Kokhan

Ural Research Institute of Dermatovenereology and Immunopathology

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Russian Federation, Ekaterinburg

Larisa S. Kruglova

Central State Medical Academy of Department of Presidential Affairs

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MD, Dr. Sci. (Med.), Professor

Russian Federation, Moscow

Olga I. Letyaeva

South-Ural State Medical University

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MD, Dr. Sci. (Med.), Professor

Russian Federation, Chelyabinsk

Andrey N. Lvov

Central State Medical Academy of Department of Presidential Affairs; Lomonosov Moscow State University

Email: alvov@mail.ru
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MD, Dr. Sci. (Med.), Professor

Russian Federation, Moscow; Moscow

Elena V. Matushevskaya

Academy of Postgraduate Education under the Federal state budgetary institution «Federal Scientific and Clinical Center for Specialized Medical Assistance and Medical Technologies of the Federal Medical Biological Agency»

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ORCID iD: 0000-0003-4583-0617
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MD, Dr. Sci. (Med.), Professor

Russian Federation, Moscow

Tatiana V. Medvedeva

Research Institute of Medical Mycology named after P.N. Kashkin of North-Western State Medical University named after I.I. Mechnikov

Email: medvedeva43@mail.ru
ORCID iD: 0000-0002-6983-6071
SPIN-code: 5494-6144

MD, Cand. Sci. (Med.), Assistant Professor

Russian Federation, Saint Petersburg

Natalia B. Migacheva

Samara State Medical University

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SPIN-code: 1313-9021

MD, Dr. Sci. (Med.), Assistant Professor

Russian Federation, Samara

Konstantin N. Monakhov

Academician I.P. Pavlov First St. Petersburg State Medical University

Email: knmonakhov@gmail.com
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SPIN-code: 1837-2098

MD, Dr. Sci. (Med.), Professor

Russian Federation, Saint Petersburg

Nikolay N. Murashkin

Central State Medical Academy of Department of Presidential Affairs; National Medical Research Center of Children’s Health; First Sechenov Moscow State Medical University (Sechenov University)

Email: m_nn2001@mail.ru
ORCID iD: 0000-0003-2252-8570
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MD, Dr. Sci. (Med.)

Russian Federation, Moscow; Moscow; Moscow

Olga B. Nemchaninova

Novosibirsk State Medical University

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MD, Dr. Sci. (Med.), Professor

Russian Federation, Novosibirsk

Natalia M. Nenasheva

Russian Medical Academy of Continuous Professional Education

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MD, Dr. Sci. (Med.), Professor

Russian Federation, Moscow

Olga Yu. Olisova

First Sechenov Moscow State Medical University (Sechenov University)

Email: olisovaolga@mail.ru
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MD, Dr. Sci. (Med.), Professor

Russian Federation, Moscow

Olga V. Pravdina

Omsk State Medical University

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MD, Cand. Sci. (Med.), Assistant Professor

Russian Federation, Omsk

Olga A. Pritulo

Medical Academy named after S.I. Georgievsky of V.I. Vernadsky Crimean Federal University

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SPIN-code: 2988-8463

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Russian Federation, Simferopol

Marina N. Repetskaya

Perm State Medical University

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MD, Dr. Sci. (Med.), Professor

Russian Federation, Perm

Nadezhda V. Romanova

Yaroslavl State Medical University

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Russian Federation, Yaroslavl

Alexey V. Samtsov

Military medical academy of S.M. Kirov

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Russian Federation, Saint Petersburg

Olga A. Sidorenko

Rostov State Medical University

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Russian Federation, Rostov-on-Don

Elena S. Snarskaya

First Sechenov Moscow State Medical University (Sechenov University)

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MD, Dr. Sci. (Med.), Professor

Russian Federation, Moscow

Evgeny V. Sokolovskiy

Academician I.P. Pavlov First St. Petersburg State Medical University

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Russian Federation, Saint Petersburg

Olga B. Tamrazova

Peoples’ Friendship University of Russia

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MD, Dr. Sci. (Med.), Professor

Russian Federation, Moscow

Natalia S. Tataurshchikova

Peoples’ Friendship University of Russia

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Elena S. Fedenko

National Research Center — Institute of Immunology Federal Medical-Biological Agency of Russia

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Russian Federation, 24, Kashirskoyw shosse, Moscow, 115522

Natalia V. Fedotova

Scientific Research Institute ― Ochapovsky Regional Clinic Hospital

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Russian Federation, Krasnodar

Natalia V. Shartanova

National Research Center — Institute of Immunology Federal Medical-Biological Agency of Russia

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Russian Federation, 24, Kashirskoyw shosse, Moscow, 115522

Eugenia A. Shatokhina

Central State Medical Academy of Department of Presidential Affairs; Lomonosov Moscow State University

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ORCID iD: 0000-0002-0238-6563
SPIN-code: 3827-0100

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Russian Federation, Moscow; Moscow

Luiza A. Yusupova

Kazan State Medical Academy under the Russian Medical Academy of Continuous Professional Education

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Russian Federation, Kazan

References

  1. Kruglova LS, Lvov AN, Araviyskaya ER, et al. Practical issues on the application of emollients containing filaggrin modulators in the management of patients with atopic dermatitis and xerosis. Resolution of the Council of experts. Kremlin Medicine Journal. 2022;1:87–94. (in Russ) doi: 10.26269/m4bj-f167
  2. Bragina EE. Filagrin and keratins in the formation of a protective barrier. Plastic Sur Cosmetology. 2011;(4):651–660. (In Russ).
  3. Barker JN, Palmer CN, Zhao Y, et al. Null mutations in the filaggrin gene (FLG) determine major susceptibility to early-onset atopic dermatitis that persists into adulthood. J Invest Dermatol. 2007;127(3):564–567. doi: 10.1038/sj.jid.5700587
  4. Ehrhardt P, Brandner Johanna M, Jens-Michael J. The skin: an indispensable barrier. Experimental Dermatol. 2008;17(12): 1063–1072. doi: 10.1111/j.1600-0625.2008.00786.x
  5. Proksch E, Brandner JM, Jensen JM. The skin: an indispensable barrier. Exp Dermatology. 2008;17(12):1063–1072. doi: 10.1111/j.1600-0625.2008.00786.x
  6. Presland RB, Fleckman P, Haydock PV, et al. Characterization of the human epidermal profilaggrin gene: Genomic organization and identification of an S-100-like calcium binding domain at the amino terminus. J Biol Chem. 1992;267(33):23772–23781.
  7. Irvine AD, McLean WH, Leung DY. Filaggrin mutations associated with skin and allergic diseases. N Engl J Med. 2011;365(14): 1315–1327. doi: 10.1056/NEJMra1011040
  8. Araviyskaya ER, Sokolovsky EV. Dry skin. Causes of occurrence. Principles of correction. Dermatovenerology Cosmetology. 2002;(2): 23–25. (In Russ).
  9. Funikova A. Atopic dermatitis. New aspects of pathogenesis, modern research. Criteria for diagnosis. Cosmetologist. 2013;(1). (In Russ).
  10. Komova EG, Shintyapina AB, Makarova SI, et al. Filaggrin mutations in a Western Siberian population and their association with atopic dermatitis in Children. Genet Test Mol Biomarkers. 2014;18(12):791–796. doi: 10.1089/gtmb.2014.0247
  11. Smith FJ, Irvine AD, Terron-Kwiatkowski A, et al. Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris. Nat Genet. 2006;38(3):337–342. doi: 10.1038/ng1743
  12. Sandilands A, O’Regan GM, Liao H, et al. Prevalent and rare mutations in the gene encoding filaggrin cause ichthyosis vulgaris and predispose individuals to atopic dermatitis. J Invest Dermatol. 2006;126(8):1770–1775. doi: 10.1038/sj.jid.5700459
  13. Clark AG, Hubisz MJ, Bustamante CD, et al. Ascertainment bias in studies of human genome-wide polymorphism. Genome Res. 2005;15(11):1496–1502. doi: 10.1101/gr.4107905
  14. Visser MJ, Landeck L, Campbell LE, et al. Impact of atopic dermatitis and loss-of-function mutations in the filaggrin gene on the development of occupational irritant contact dermatitis. Br J Dermatol. 2013;168(2):326–332. doi: 10.1111/bjd.12083
  15. McAleer MA, Irvine AD. The multifunctional role of filaggrin in allergic skin disease. J Allergy Clin Immunol. 2013;131(2):280–291. doi: 10.1016/j.jaci.2012.12.668
  16. Liljedahl RE, Johanson G, Korres de Paula H, et al. Filaggrin polymorphisms and the uptake of chemicals through the skin-a human experimental study. Environ Health Perspect. 2021;129(1):17002. doi: 10.1289/EHP7310
  17. Brown SJ, Kroboth K, Sandilands A, et al. Intragenic copy number variation within filaggrin contributes to the risk of atopic dermatitis with a dose-dependent effect. J Invest Dermatol. 2012;132(1): 98–104. doi: 10.1038/jid.2011.342
  18. Volosovets AP, Krivopustov SP, Pavlik EV. The role of filaggrin in the allergology of childhood. Child’s Health. 2013;(2): 156–161. (In Russ).
  19. Maksimova YV, Svechnikova EV, Maksimov VN, Lykova SG. Heredity and atopic dermatitis [Electronic resource]. Med Education Siberia: Online Scientific Publication. 2013;(6). (In Russ).
  20. Rupnik H, Rijavec M, Korošec P. Filaggrin loss-of-function mutations are not associated with atopic dermatitis that develops in late childhood or adulthood. Br J Dermatol. 2015;172(2):455–461. doi: 10.1111/bjd.13477
  21. Brown SJ, Irvine AD. Atopic eczema and the filaggrin story. Semin Cutan Med Surg. 2008;27(2):128–137. doi: 10.1016/j.sder.2008.04.001
  22. Thaçi D, Simpson EL, Beck LA, et al. Efficacy and safety of dupilumab in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical treatments: a randomised, placebo-controlled, dose-ranging phase 2b trial. Lancet. 2016;387(10013): 40–52. doi: 10.1016/S0140-6736(15)00388-8
  23. Cornelissen C, Marquardt Y, Czaja K, et al. IL-31 regulates differentiation and filaggrin expression in human organotypic skin models. J Allergy Clin Immunol. 2012;129(2):426–433, 433.e1-8. doi: 10.1016/j.jaci.2011.10.042
  24. Sandilands A, Sutherland C, Irvine AD, McLean WH. Filaggrin in the frontline: role in skin barrier function and disease. J Cell Sci. 2009;122(Pt 9):1285–1294. doi: 10.1242/jcs.033969
  25. Belozerova AP. Indicators of sensitization to antigens of opportunistic fungi Malassezia and Candida in patients with allergodermatoses with mutations of the filaggrin gene. Dermatol Venereol. 2011;(4):24. (In Russ).
  26. Heede NG, Thyssen JP, Thuesen BH, et al. Anatomical patterns of dermatitis in adult filaggrin mutation carriers. J Am Acad Dermatol. 2015;72(3):440–448. doi: 10.1016/j.jaad.2015.01.001
  27. Active Epidermal Moisturization: Filaggrin Modulator from Fractions of vegetable Unsaponifiables. Lexicon Vevy Europe. 2011;(1):1–4.
  28. Presland RB, Boggess D, Lewis SP, et al. Loss of normal profilaggrin and filaggrin in flaky tail (ft/ft) mice: an animal model for the filaggrin-deficient skin disease ichthyosis vulgaris. J Invest Dermatol. 2000;115(6):1072–1081. doi: 10.1046/j.1523-1747.2000.00178.x
  29. Smith FJ, Irvine AD, Terron-Kwiatkowski A, et al. Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris. Nat Genet. 2006;38(3):337–342. doi: 10.1038/ng1743
  30. Favre A, Donetti M. Studio istochimico dell’ATPasi dopo applicazione cutanea di Filagrinol. Lexicon Vevy. 1987;(4):49–51.
  31. Rialdi G, Hauf E. Evaluation of the effects of Filagrinol on human skin. Lexicon Vevy. 1988;(3):30–38.
  32. Rialdi G, Hauf E. Biochemical Evaluation of Filagrinol protection on the skin aspect through time (skin momentum). Lexicon Vevy Europe. 1988;2:16–20.
  33. Zaslavsky DV, Sobolev AV, Skrek SV, et al. Normalization of the epidermal barrier as a method of pathogenetic therapy of atopic dermatitis in children. Bulletin Dermatol Venereol. 2021;97(5):52–65. (In Russ). doi: 10.25208/vdv1255
  34. Murashkin NN, Ivanov RA, Ambarchyan ET, et al. Filaggrin and atopic dermatitis: clinical and pathogenetic parallels and possibilities of therapeutic correction. Issues Modern Pediatrics. 2021;20(5): 435–440. doi: 10.15690/vsp.v20i5.2320

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Copyright (c) 2022 Araviyskaya E.R., Bakulev A.L., Gadzhigoroeva A.G., Elisyutina O.G., Zagrtdinova R.M., Zaslavsky D.V., Ziganshin O.R., Ignatovsky A.V., Kokhan M.M., Kruglova L.S., Letyaeva O.I., Lvov A.N., Matushevskaya E.V., Medvedeva T.V., Migacheva N.B., Monakhov K.N., Murashkin N.N., Nemchaninova O.B., Nenasheva N.M., Olisova O.Y., Pravdina O.V., Pritulo O.A., Repetskaya M.N., Romanova N.V., Samtsov A.V., Sidorenko O.A., Snarskaya E.S., Sokolovskiy E.V., Tamrazova O.B., Tataurshchikova N.S., Fedenko E.S., Fedotova N.V., Shartanova N.V., Shatokhina E.A., Yusupova L.A.

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