电邮这篇文章 下肢动脉硬化闭塞症不利过程的遗传预测因子
- 作者: Kalinin R.E.1, Suchkov I.A.1, Chobanyan A.A.1, Nikiforov A.A.1, Shumskaya E.I.1
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隶属关系:
- Ryazan State Medical University
- 期: 卷 29, 编号 2 (2021)
- 页面: 251-256
- 栏目: Original study
- URL: https://bakhtiniada.ru/pavlovj/article/view/65383
- DOI: https://doi.org/10.17816/PAVLOVJ65383
- ID: 65383
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详细
目的：检测LIPC基因多态性–250G>A和MMP-1基因多态性–1607insG对下肢动脉硬化闭塞症（ASO）过程的影响。
材料与方法。共有76人参加了该研究。第I组（n=34）包括在发病5年内出现严重下肢缺血的ASO病程不佳（进行性）的患者。第II组（n=34）包括有条件有利（非进行性）病程的患者。这些患者发病5年内没有出现严重下肢缺血，慢性缺血程度没有进展。对照组（n=8）包括所有血管盆中无动脉粥样硬化征象的健康志愿者。对患者进行了多态性LIPC-250G>A和MMP-1-1607ins的基因分型。观察频率和期望频率之间的差异是根据皮尔逊卡方标准估计的，调整了可能性。
结果。通过对LIPC基因–250G>A多态性的研究，发现ASO患者组和健康志愿者组的观察频率和预期频率差异有统计学意义（p=0.013）。第I组和第II组的评价也显示了观察频率和预期频率的差异（p=0.004）。杂合载体（GA基因型）与ASO不良病程发展风险增加有关。风险比率=2133，95%置信区间为1214—3748。在分析MMP1基因多态性-1607insG 时，第I组与第II组比较（p=0.128）， ASO患者组与健康志愿者比较（p=0.38）均无统计学意义。
结论。LIPC –250G>A杂合携带与发展一种不利类型的ASO疗程的风险增加相关。对这一多态性的研究可用于新诊断的下肢动脉硬化闭塞症的患者，以确定疾病的预后，特别是年轻患者的早期表现和有沉重的遗传史。MMP1基因的多态性–1607insG对ASO的发病过程没有影响。
关键词
作者简介
Roman Kalinin
Ryazan State Medical University
Email: kalinin-re@yandex.ru
ORCID iD: 0000-0002-0817-9573
MD, Dr.Sci.(Med.), Professor, Head of the Department of Cardiovascular, X-Ray Endovascular, Operative Surgery and Topographic Anatomy
俄罗斯联邦, RyazanIgor Suchkov
Ryazan State Medical University
编辑信件的主要联系方式.
Email: suchkov_med@mail.ru
ORCID iD: 0000-0002-1292-5452
MD, Dr.Sci.(Med.), Professor, Professor of the Department of Cardiovascular, X-Ray Endovascular, Operative Surgery and Topographic Anatomy
俄罗斯联邦, RyazanArtem Chobanyan
Ryazan State Medical University
Email: artaleksandrovich@gmail.com
ORCID iD: 0000-0002-8129-5976
PhD-Student of the Department of Cardiovascular, X-ray Endovascular, Operative Surgery and Topographic Anatomy
俄罗斯联邦, RyazanAleksandr Nikiforov
Ryazan State Medical University
Email: alnik003@yandex.ru
ORCID iD: 0000-0002-7364-7687
MD, Cand.Sci.(Med.), Head of the Central Research Laboratory
俄罗斯联邦, RyazanEvgenia Shumskaya
Ryazan State Medical University
Email: shumsckaya.ev@yandex.ru
Assistant of the Department of Histology, Pathological Anatomy and Medical Genetics
俄罗斯联邦, Ryazan参考
- Kalinin RE, Suchkov IA, Mzhavanadze ND, et al. Comparison of cytotoxicity of vascular prostheses in vitro. I.P. Pavlov Russian Medical Biological Herald. 2020;28(2):183-92. (In Russ). doi: 10.23888/PAVLOVJ2020282183-192
- Dua A, Lee CJ. Epidemiology of Peripheral Arterial Disease and Critical Limb Ischemia. Techniques in Vascular and Interventional Radiology. 2016;19(2):91-5. doi: 10.1053/j.tvir.2016.04.001
- Adam DJ, Bradbury AW. TASC II Document on the Management of Peripheral Arterial Disease. European Journal of Vascular and Endovascular Surgery. 2007;33(1):1-2. doi: 10.1016/j.ejvs.2006.11.008
- Kalinin RE, Egorov AA, Suchkov IA, et al. Effect of genetic polymorphisms on functioning of a permanent vascular access in patients on dialysis. Angiology and Vascular Surgery. 2019;25(1):40-4. (In Russ). doi: 10.33529/angio2019105
- Starodubova YuN, Osipova IV. Characteristics of dyslipidemia and the duration of rheumatoid arthritis in women. Ateroscleroz. 2017;13(3):33-42. (In Russ).
- Vilms EA, Dolgikh TI, Turchaninov DV. The prevalence of polymorphisms of genes, associated with socially significant multifactor diseases of Omsk population. Medical Almanac. 2012;(3):169-72. (In Russ).
- Valdivielso P, Ariza MJ, Vega-Román C, et al. Association of the -250G/A promoter polymorphism of the hepatic lipase gene with the risk of peripheral arterial disease in type 2 diabetic patients. Journal of Diabetes and its Complications. 2008;22(4):273-7. doi: 10.1016/j.jdiacomp.2007.06.011
- Djazaeva МB, Gladkikh NN, Reshetnikov VA, et al. Matrix metalloproteinases: role in cardiac remodeling in patients with connective tissue dysplasia. Medical News of North Caucasus. 2018;13(4):576-80. (In Russ). doi: 10.14300/mnnc.2018.13108
- Kalinin RE, Suchkov IA, Pshennikov AS, et al. Application of Magnesium Drugs and Their Influence on the Indicators of Connective Tissue Dysplasia in Patients with Varicose Veins. Novosti Khirurgii. 2018;26(1):51-9. doi: 10.18484/2305-0047.2018.1.51
- Lin J, Kakkar V, Lu X. Impact of matrix metalloproteinases on atherosclerosis. Current Drug Targets. 2014;15(4): 442-53. doi: 10.2174/1389450115666140211115805
- Ivanoschuk DЕ, Ragino YuI, Shakhtshneider ЕV, et al. Analysis of differential expression of matrix metalloproteases in stable and unstable atherosclerotic lesions by a method of full genome sequencing of RNA: pilot study. Russian Journal of Cardiology. 2018;23(8):52-8. (In Russ). doi: 10.15829/1560-4071-2018-8-52-58
- Natsional’nyye rekomendatsii po diagnostike i lecheniyu zabolevaniy arteriy nizhnikh konechnostey. Moscow; 2019. Available at: http://www.angiolsurgery.org/library/recommendations/2019/recommendations_LLA_2019.pdf. Accessed: 2021 April 26. (In Russ).
- Chahirou Y, Mesfioui A, Ouichou A, et al. Adipokines: mechanisms of metabolic and behavioral disorders. Obesity and Metabolism. 2018;15(3):14-20. (In Russ). doi: 10.14341/OMET9430
- Kalinin RE, Suchkov IA, Chobanyan AA. Prospects for forecasting the course of obliterating atherosclerosis of lower limb arteries. Nauka Molodykh (Eruditio Juvenium). 2019;7(2):274-82. (In Russ). doi: 10.23888/HMJ201972274-282
- Bakker W, Eringa EC, Sipkema P, et al. Endothelial dysfunction and diabetes: roles of hyperglycemia, impaired insulin signaling and obesity. Cell and Tissue Research. 2009;335(1):165-89. doi: 10.1007/s00441-008-0685-6
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