电邮这篇文章 Vascularization of chorion villi in the first trimester of gestation with physiological course and in recurrent miscarriage with underlying chronic endometritis
- 作者: Peretiatko L.P.1, Fateeva N.V.1, Kuznetsov R.A.1, Malyshkina A.I.1
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隶属关系:
- Federal State Budget Establishment “Ivanovo Scientific Research Institute of Motherhood and Childhood named after V.N. Gorodkov” of the Ministry of Healthcare of the Russian Federation
- 期: 卷 25, 编号 4 (2017)
- 页面: 612-620
- 栏目: Obstetrics and gynecology
- URL: https://bakhtiniada.ru/pavlovj/article/view/6362
- DOI: https://doi.org/10.23888/PAVLOVJ20174612-620
- ID: 6362
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详细
Aim. To study stages of vasculo- and angiogenesis in uncomplicated course of the first trimester of gestation and to identify disorders in vascularization of the villous chorion in recurrent miscarriages and chronic endometritis.
Materials and Methods. The main group – villous chorion of 5-12 weeks of gestation obtained from female patients with recurrent miscarriage and chronic endometritis (n=35); comparison group – villous chorion obtained from clinically healthy females in official abortions (n=30). On the basis of the results of morphological examination the analysis of stages of vascularization of villous chorion was carried out.
Results. In recurrent miscarriage associated with chronic inflammation of the endometrium, structural changes of the villous chorion were detected manifested by retardation of differentiation of villi starting from the 5th week of gestation, by delay of vasculogenesis at the stage of formation of hemangioblastic cords typical of the 6-7th week with its inhibition in the subsequent periods. In villi of the 8-12th weeks of gestation no further differentiation of vessels was seen, hence, branched angiogenesis did not form.
Conclusion. Disorders in differentiation of villi, in vasculo- and angiogenesis in the stroma of chorion villi with the underlying chronic inflammation of the endometrium that produced negative effect on further development and successful completion of gestation, were proved.
作者简介
L. Peretiatko
Federal State Budget Establishment “Ivanovo Scientific Research Institute of Motherhood and Childhood named after V.N. Gorodkov” of the Ministry of Healthcare of the Russian Federation
Email: nata6120@bk.ru
ORCID iD: 0000-0003-1047-6312
SPIN 代码: 2795-9185
MD, Grand PhD, Head of Laboratory of Pathomorphology and Electronic Microscopy
俄罗斯联邦, Pobeda str., 20, 153045, IvanovoN. Fateeva
Federal State Budget Establishment “Ivanovo Scientific Research Institute of Motherhood and Childhood named after V.N. Gorodkov” of the Ministry of Healthcare of the Russian Federation
编辑信件的主要联系方式.
Email: nata6120@bk.ru
ORCID iD: 0000-0002-4077-3310
SPIN 代码: 5817-1380
Postgraduate, Junior Research Assistant of Laboratory of Pathomorphology and Electronic Microscopy
俄罗斯联邦, Pobeda str., 20, 153045, IvanovoR. Kuznetsov
Federal State Budget Establishment “Ivanovo Scientific Research Institute of Motherhood and Childhood named after V.N. Gorodkov” of the Ministry of Healthcare of the Russian Federation
Email: rakuzz@mail.ru
ORCID iD: 0000-0001-6061-2955
SPIN 代码: 1285-4151
MD, PhD, Junior Research Assistant of Laboratory of Pathomorphology and Electronic Microscopy
俄罗斯联邦, Pobeda str., 20, 153045, IvanovoA. Malyshkina
Federal State Budget Establishment “Ivanovo Scientific Research Institute of Motherhood and Childhood named after V.N. Gorodkov” of the Ministry of Healthcare of the Russian Federation
Email: uprdelnii@mail.ru
ORCID iD: 0000-0002-1145-0563
SPIN 代码: 7937-9125
MD, Grand PhD, Associate Professor, Director of “V.N. Gorodkov Scientific and Research Institute of Motherhood and Childhood of Ivanovo”, MH RF
俄罗斯联邦, Pobeda str., 20, 153045, Ivanovo参考
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