Disadaptive genetic-evolutionary processes in human populations of industrial cities

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Abstract

Aim. Generalization of literature and proprietary data on genetic-physiological and evolutionary processes occurring in human populations in environmentally neglected industrial cities.

In the review information is given about damage to the genetic apparatus of cells of a human organism under influence of unfavorable environmental factors and disadaptations of different
genesis. To denote the totality of alterations induced by the given exposure, a new term is introduced – ‘genetics of disadaptations’. The information of mutagenic factors of the environment of industrial cities associated with growth of oncological diseases and of malformations resulting from chromosomal aberrations in cells is generalized. The problem of genetic burden of human populations
in environmentally neglected territories and of the influence of disadaptive factors on this process is discussed. Information of the ecological situation and morbidity of the population in Cherepovets industrial city is given. A role of disadaptations in genetic-evolutionary processes occurring in
human populations is shown. The cause of different manifestations of disadaptation in the population is stated to be divergence of traits. A hypothesis is proposed and evidences are given in favor of the existence of natural selection for a disadaptive trait in human populations. It is suggested that being accumulated in a human organism, disadaptive disorders may be transmitted to the next
generations reducing vital ability of organisms and inducing different diseases.

Conclusion. Within the topic, examples of different prophylactic measures for improving the health of the population of industrial cities are given to prevent unfavorable alterations of human genome under the influence of unfavorable ecological and related disadaptive factors.

About the authors

Aleksey A. Artemenkov

Cherepovets State University

Author for correspondence.
Email: basis@live.ru
ORCID iD: 0000-0001-7919-3690
SPIN-code: 9516-2356

PhD in Biological Sciences, Associate Professor, Corresponding Member of the Russian Academy of Natural Sciences, Acting Head of the Department of Theoretical Foundations of Physical Culture, Sports and Health at the Faculty of Biology and Human Health

Russian Federation, Cherepovets

References

  1. Voronina TA. The role of oxidative stress and antioxidants in different disadapation genesis. Pharmacy & Pharmacology. 2015;(S1):8-17. (In Russ).
  2. Ingel FI. Quality of life and individual susceptibility of human genome. Whether there is an exit from a vicious circle? Ecological Genetics. 2005;3(3):38-45. (In Russ).
  3. Ingel' FI, Krivtsova EK, Urtseva NA, et al. Volatility and sensitivity of the genome of healthy children in Magnitogorsk. Hygiene and Sanitation. 2013;(3): 20-7. (In Russ).
  4. Wu Y, Peterson KE, Sánchez BN, et al. Association of blood leukocyte DNA methylation at LINE-1 and growth-related candidate genes with pubertal onset and progression. Epigenetics. 2018;13(12):1222-33. doi: 10.1080/15592294.2018.1556198
  5. Vodicka P, Musak L, Vodickova L, et al. Genetic variation of acquired structural chromosomal aberrations. Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 2018;836(Pt A):13-21. doi: 10.1016/j.mrgentox.2018.05.014
  6. Dyuzhikova NA, Daev EV. Genome and stress-reaction in animals and humans. Ecological Genetics. 2018;16(1):4-26. (In Russ). doi: 10.17816/ecogen 1614-26
  7. Li R, Wang X, Wang B, et al. Gestational 1-nitro-pyrene exposure causes fetal growth restriction through disturbing placental vascularity and prolife-ration. Chemosphere. 2018;213:252-8. doi:10.1016/ j.chemosphere.2018.09.059
  8. Golivets TP, Kovalenko BS, Parshkov EM. Population patterns of development of cancer incidence. Scientific Bulletins of Belgorod State University. Series: Medicine. Pharmacia. 2014;18(189; Pt 27):166-9. (In Russ).
  9. Fu W, Chen Z, Bai Y, et al. The interaction effects of polycyclic aromatic hydrocarbons exposure and TERT- CLPTM1L variants on longitudinal telomere length shortening: A prospective cohort study. Environmental Pollution. 2018;242(Pt B):2100-10. doi: 10.1016/j.envpol.2018.05.026
  10. Bobyleva LA. Chemical mutagenesis and the problems of ecological safety of population of industrial cities. Modern High Technologies. 2015;(12):590-4. (In Russ).
  11. Kaverin AV, Shchankin AA, Shchankina GI. Impact of environmental factors on physical development and population health. Mordovia University Bulletin. 2015;25(2):87-97. (In Russ). doi:10.15507/ VMU.025.201502.087
  12. Drach LA. The influence of environmental factors on populance health: frequency of congenital cataract among population of Kramatorsk city (2004-2006). In: Problemi ekologìčnoï ta medičnoï genetiki ì klìnìčnoï ìmunologìï. 2010;4(100):374-81. (In Russ). Available at: http://ecoproblemlug.ucoz.ua/ load/2010/4_100/drach_l_o_vpliv_faktoriv_dovko-lishnogo_seredovishha_na_zdorov_ja_naselennja_ chastota_vrodzhenoji_katarakti_sered_naselennja_ m_kramatorska_2004_2/31-1-0-1511. Accessed: 2019 December 15.
  13. Shemetun OV, Talan OO, Demchenko OM, et al. Development of radiation-induced bystander effect in the somatic cells of persons from different age groups. Problems of radiation medicine and radiobiology. 2018;23:499-509. doi: 10.33145/2304-8336 -2018-23-499-509
  14. Chshiyeva FT. Cytogenetic analysis of residents of North Ossetia contacting with toxic factors. Ecolo-gical Genetics. 2014;12(2):68-73. (In Russ).
  15. Chshiyeva FT. Cytogenetic analysis of the residents of North Ossetia living in ecologically different regions. Ecological Genetics. 2014;12(3):87-94. (In Russ).
  16. Minina VI, Druzhinin VG, Golovina TA, et al. Dynamics of chromosomal aberrations level in residents of an industrial city in conditions of changing atmosphere pollution. Ecological Genetics. 2014; 12(3):60-70. (In Russ).
  17. Jamebozorgi I, Majidizadeh T, Pouryagoub G, et al. Aberrant DNA Methylation of Two Tumor Suppressor Genes, p14ARF and p15INK4b, after Chronic Occupational Exposure to Low Level of Benzene. The International Journal of Occupational and Environmental Medicine. 2018;9(3):145-51. doi:10.15 171/ijoem.2018.1317
  18. Liu Y, Zhang H, Zhang H, et al. Mediation effect of AhR expression between polycyclic aromatic hydrocarbons exposure and oxidative DNA damage among Chinese occupational workers. Environmental Pollution. 2018;243(Pt B):972-7. doi:10.1016/ j.envpol.2018.09.014
  19. Volkov AN, Druzhinin VG, Minina VI, et al. Research of the influence of Lig4 gene polimorphism on chromosomal aberrations level IN human lymphocytes, with background and excessive exposure to radon. Ecological Genetics. 2013;11(2):16-21. (In Russ).
  20. Bayravov NA, Zhilyakov EV. Anthropogenic load as a contributor to the development and course of major diseases of pregnant women and children. Fundamental Research. 2014;(4-3):624-8. Available at: https:// fundamental-research.ru/ru/article/view?id=33973. Accessed: 2019 December 15. (In Russ).
  21. Mukhina MV, Shevchenko SM, Frolova K.A. Analysis of the environment of a large industrial city. Russian Journal of Resources, Conservation and Recycling. 2018;5(1):7. Available at: https:// resources. today/PDF/08NZOR118.pdf. Accessed: 2019 December 15. (In Russ). doi: 10.15862/08NZOR11
  22. Villarini M, Levorato S, Salvatori T, et al. Buccal micronucleus cytome assay in primary school children: A descriptive analysis of the MAPEC_LIFE multicenter cohort study. International Journal of Hygiene and Environmental Health. 2018;221(6): 883-92. doi: 10.1016/j.ijheh.2018.05.014
  23. Iztleuov MK, Iztleuov EM. Vlijanie proizvodstvennyh faktorov hromovogo proizvodstva na reproduktivnuju funkciju rabochih. Akademicheskij Zhurnal Zapadnoj Sibiri. 2013;9(3):85. (In Russ).
  24. Bachina AV, Kos'kina EV, Glebova LA, et al. Hygienic support for the regional model of congenital anomalies monitoring in Kuzbass. Medicine in Kuzbass. 2017;16(1):30-9. (In Russ).
  25. Zhang LN, Gong XS, An J, et al. Occurrence, degradation and potential ecological risks of triclosan in environment. Ying Yong Sheng Tai Xue Bao. 2018; 29(9):3139-46. doi: 10.13287/j.1001-9332.201809.033
  26. Ospanova EN, Askambay K. Prevalence and reasons for the emergence of perinatal pathology of central nervous system (PPCNS) among children in shymkent, the South Kazakhstan region. Fundamental Research. 2014;(4-1):129-32. Available at: http://fundamental-research.ru/ru/article/view?id= 33681. Accessed: 2019 December 15. (In Russ).
  27. Zhou Q, Xi S. A review on arsenic carcinogenesis: Epidemiology, metabolism, genotoxicity and epigenetic changes. Regulatory Toxicology and Pharmacology. 2018;99:78-88. doi: 10.1016/j.yrtph.2018.09.010
  28. Sauchanka VK. Contribution of human genome and environment to shaping health of society. HealthCare (Minsk). 2016;(3):21-35. (In Russ).
  29. Balajee AS, Hande MP. History and evolution of cytogenetic techniques: Current and future applications in basic and clinical research. Mutation Research. Genetic Toxicology and environmental mutagenesis. 2018;836(Pt A):3-12. doi: 10.1016/j.mr gentox.2018.08.008
  30. Aburakhmanov GM, Bekshokova PA, Gabibova PI. Quality of life study of population of Dakhadaev region in Dagestan Republic using the SF-36 questionnaire. Bulletin of the Multinational Center of Quality of Life Research. 2015;(25-26):27-36. (In Russ).
  31. Kiku PF, Gigaev DS, Shiter NS, et al. The concept of risk factors for the health of the population. Bulletin Physiology and Pathology of Respiration. 2016;(62):101-9. (In Russ). doi: 10.12737/23260
  32. Puzyrev VP, Nazarenko LP, Lebedev IN. Genetic load and orphan diseases in siberian populations. The Bulletin of Siberian Branch of Russian Academy of Medical Sciences. 2013;33(2):54-62. (In Russ).
  33. Khetagurova LG, Datieva FS, Tagaeva IR, et al. Search of possibility of integrative approach use in the analysis of the genetic polymorphism role in the development of desynchronosis and socially important diseases of cvd from the view of chronomedicine. Vladikavkazskij Mediko-Biologicheskij Vestnik. 2012;15(23):21-25. (In Russ).
  34. Gordeeva LA, Voronina EN, Sokolova EA, et al. Association GSTT1, GSTM1 and GSTP1 (Ile105Val) genetic polymorphisms in mothers with risk of congenital malformations in their children in Western Siberia: a case-control study. Prenatal Diagnosis. 2013;33(11):1095-101. doi: 10.1002/pd.4204
  35. Nabokova LV, Chopikashvili LV, Puhaeva EG. Zdorov'e naselenija goroda Vladikavkaza RSO – Alanija, kak sledstvie sinergizma antropogennyh faktorov sredy. Jelektronnyj sbornik nauchnyh trudov «Zdorov'e i obrazovanie v XXI Veke». 2011; 13(10):478-80. (In Russ).
  36. Bessonova LA, El'chinova GI, Zinchenko RA. Population genetics of hereditary diseases in the child population of the Republic of Bashkortostan, Chuvashia, and Udmurtia. Russian Journal of Genetics. 2012;48(5):644-54. (In Russ).
  37. Zinchenko RA, Osipova EV, Elchinova G.I., et al. Factors of population dynamics determining the load of hereditary diseases in subpopulations of udmurt republic. Zdorov'e, Demografija, Jekologija Finno-Ugorskih Narodov. 2012;(1):37-42. (In Russ).
  38. Amelina SS, Vetrova NV, Ponomareva TI, et al. The load of hereditary diseases in the twelve districts of the Rostov region. Journal of Health and Life Sciences. 2014;(2):43-8. (In Russ).
  39. Amelina SS, Vetrova NV, Amelina MA, et al. The load and diversity of hereditary diseases in four raions of Rostov oblast. Russian Journal of Genetics. 2014;50(1):91-9. (In Russ). doi: 10.7868/S001 6675814010020
  40. Makaov AKh, Kutsev SI, Zinchenko RA. Medical genetics and population study of Karachaevsk and Karachayevsky district Karachai-Cherkess republic. Eurazian Union Scientist. 2016;(1-4):73-5. (In Russ).
  41. Yablokov AV, Levchenko VF, The Decision Exists: Transition to Controlled Evolution of the Biosphere. Philosophy and Cosmology. 2015;14:91-117. (In Russ).
  42. Pal AK, Ambulkar PS, Waghmare JE, et al. Chromosomal Aberrations in Couples with Pregnancy Loss: A Retrospective Study. Journal of Human Reproductive Sciences. 2018;11(3):247-53. doi:10. 4103/jhrs.JHRS_124_17
  43. Barouki R, Audouze K, Coumoul X, et al. Integration of the human exposome with the human genome to advance medicine. Biochimie. 2018;152:155-8. doi: 10.1016/j.biochi.2018.06.023
  44. Artemenkov AA. Change in clinic-physiological parameters of students of industrial center. Scientific Bulletins of Belgorod State University. Series: Me-dicine. Pharmacia. 2016;35(19):67-71. (In Russ).
  45. Artemenkov AA. Ecological aspects of hygiene noncommunicable diseases of adult population of large industrial city. Public Health and Life Environment. 2017;(4):7-10. (In Russ).
  46. Artemenkov AA. Disadaption as a factor of evolution development in human populations. Abstract Journal «Scientific review». 2017;(1):5-6. Available at: http://abstract.science-review.ru/ru/article/view? id=1839. Accessed 2019 December 15. (In Russ).
  47. Stepanov VA. Evolution of genetic diversity and human diseases. Russian Journal of Genetics. 2016; 52(7):852-64. (In Russ). doi: 10.7868/S0016675816 070109
  48. Haque S. Frequency of XRCC1 Exon 9 G>A gene polymorphism in Saudi Arabian population: A comparative study with worldwide ethnic groups. Journal of Balkan Union of Oncology. 2018;23(4):1195-9.
  49. Malyarchuk BA, Derenko MV. Genomic studies of aboriginal populations of the North-East Asia. Vestnik Dal'nevostochnogo otdelenija Rossijskoj akademii nauk. 2017;(5):72-7. (In Russ).
  50. Eltsov NP, Volod'ko NV, Starikovskaya EB, et al. The Role of Natural Selection in the Evolution of Mitochondrial Haplogroups from Northeastern Eurasia. Russian Journal of Genetics. 2010;46(9):1247-9. (In Russ).
  51. Tetior AN. Problems of binary plural evolution of person. Nacional'naja associacija uchenyh. 2015;4-6(9):129-33. Available at: https://national-science. ru/wp-content/uploads/2016/02/national_9_p6_6-173.pdf. Accessed 2019 December 15. (In Russ).
  52. Mooney JA, Huber CD, Service S, et al. Understanding the Hidden Complexity of Latin American Population Isolates. American Journal of Human Genetics. 2018;103(5):707-26. doi: 10.1016/j.ajhg.2018.09.013
  53. Giuliani C, Garagnani P, Franceschi C. Genetics of Human Longevity Within an Eco-Evolutionary Nature-Nurture Framework. Circulation Research. 2018;123(7):745-72. doi: 10.1161/CIRCRESAHA. 118.312562
  54. Lacina L, Čoma M, Dvořánková B, et al. Evolution of Cancer Progression in the Context of Darwinism. Anticancer Research. 2019;39(1):1-16. doi:10.21873/ anticanres.13074
  55. Kuo HW. Health Without Borders: Creating Healthy Cities. Hu li za zhi The journal of nursing. 2018; 65(5):27-33. doi: 10.6224/JN.201810_65(5).05
  56. Artemenkov AA. Genetic, Physiological, and Evolutionary Significance of Maladaptation (Review). Journal of Medical and Biological Research. 2018;6(4):319-31. (In Russ). doi: 10.17238/issn 2542-1298.2018.6.4.319
  57. Fenster CB, Ballou JD, Dudash MR, et al. Conservation and Genetics. The Yale Journal of Biology and Medicine. 2018;91(4):491-501.

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2. Fig. 1. Disadaptive divergence of characteristics in human populations [46]. Types of disadaptation:D – disadaptive; CD – completely disadapted; PD – partially disadapted; PA – partially adapted; Intpsy – intermediate with predomination of psychological disadaptation; Intphys – intermediate with predomination of physical disadaptation; Intphysiol – intermediate with predomination of physiological disadaptation; A – adapted

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3. Fig. 2. Disadapting form of selection in human population [46]

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Copyright (c) 2020 Artemenkov A.A.

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