Metabolic basis of burn intoxication and ways of detoxification therapy

The pathogenesis of burn toxemia is one of the central problems of combustiology. Due to the successes of antishock therapy, burn mortality is currently observed mainly not in the state of shock, but in the periods of toxemia and septicotoxemia. There is an urgent need to study the pathogenesis of endogenous intoxication after thermal injuries and develop the most promising ways of detoxification therapy. Clearly, this requires the solution of a number of interrelated issues: clarification of the nature of pathochemical reactions in relation to the function of various organs and systems, their dependence on the area and depth of the lesion, the nature of the toxic products that determine the changes occurring, and finally, the appropriate ways of their inactivation or removal from the body. Most of the above questions have been studied for a number of years by the staff of the Biochemistry Department of Chelyabinsk Medical Institute and the Regional Burn Center, which is the clinical base of the department.