Clinical and physiological study of the action of aminophylline in patients with chronic cor pulmonale

In a report previously published by B. B. Kogan and P. M. Zlochevsky, positive ECG shifts are described, and in some cases a decrease in the amplitude of the second tone in the pulmonary artery, according to phonocardiography, under the influence of intravenous administration of aminophylline in patients with chronic cor pulmonale in reversible stages of decompensation. Produced in 5 patients synchronously with ECG of right atrial catheterization (M.V. Muravyov) found that under the influence of aminophylline introduced through a probe directly into the heart cavity, along with a decrease in pulmonary P, systolic pressure in the right atrium simultaneously decreases. These studies made it possible to elucidate the undoubted pathogenetic relationship between the pressure level in the small circle and the right cardiac cavities and the ECG, in particular, with the electrical activity of the right atrium, as well as the diagnostic value of the administration of aminophylline in diseases occurring with hypertension of the pulmonary circulation (aminophylline test).