On the effect of anti-syphilitic treatment on the course of menstruation in syphilitic women

It is considered established that monthly periods that come on time regularly serve as an indicator of the normal state of the female genital sphere and, conversely, a violation of the correctness of menstruation indicates a functional disorder of the sexual apparatus. The physiology and pathology of the menstrual type are so well studied that by certain changes we can judge the state of the organs involved in the menstrual cycle—namely, the ovary and uterus. The latest studies on the effect of various protein substances, as well as some drugs (for example, iodine) have shown that the organ regulating menstruation - the ovary-is quite sensitive to the introduction of these substances. From this point of view, it would not be necessary to ignore the possible influence of platypus from such strongly acting, partly toxic drugs, which are used in the treatment of syphilis. The observation of the correctness of the patient's menstrual function could serve as a clinical criterion for the state of the ovary in the treatment of syphilis. The question of the effect of specific treatment on the course of menstruation in a woman in the medical literature is still extremely little developed. So Lecaperé (in" Traitation de la syphilis") indicates that the regula in some patients during the treatment of Vi became more frequent and more abundant. Levaditi writes that metrorrhagia and erosive balanitis, accompanied by prepuce pigmentation, are cited among the most rare side effects of bismuth therapy. The same instructions are available from N. Förtig, Rudolfloffe (Handbuch der Salvarsantherapie-Kolle and Zieler). According to Mulzer, the started regula do not constitute a contraindication for continuing treatment. The most detailed question is covered and tested clinically by Kana P. Smelov, who indicate that practically a doctor with specific treatment in women has to solve such questions: 1) whether it is necessary to stop treatment during regula, 2) how specific therapeutic measures (rubbing mercury, injections, infusions) affect the type of menstruation in syphilitic women whose genitals are normal, and 3) how does treatment affect syphilitic women who already had a menstrual disorder before the start of specific treatment. With regard to the first question—therapy during menstruation, Kan and Smelov believe that in people who are sexually healthy and suffer from infectious and non-infectious diseases of a non-gynecological nature, treatment in most cases does not change the menstrual type and can continue during the regula without a break. On the second question about the effect of treatment on the type of menstruation, the following is stated: "Rational therapy (medication, physiotherapy, climatic, balneological) has a positive effect in the sense of improving the menstrual type in constitutionally low-value subjects.