To the question of the therapeutic value of overfeeding nephrotic proteins

The study of the problem of water exchange and issues of the pathogenesis of edema (Starling, Krog, Beilis, Schade, Gover, Shabanier, Kilin, etc.) made it possible to establish the colossal significance in the pathogenesis of nephrosis of a number of factors associated with the state of the body's proteins. To one degree or another, depletion of blood plasma proteins, sharp changes in the ratio of protein fractions with a shift towards the coarse-dispersed phase (globulins), an increase in the hydrophilicity of tissue colloids (McClure and Aldrich test) characterize pathological shifts in the protein economy of the body. The osmotic pressure of nephrotic plasma proteins drops sharply due to an increase in osmotically much less active globulins and fibrinogen (Schade, Shabanier, Gover, Kilin, Malkin, etc.). This decrease can in some cases reach a value of 10-14 cm of water column in comparison with the normal value of 30-40 cm (Gover, Golikov). According to modern views, these violations of the protein constant due to changes in the salt balance, in the state of permeability of the capillary wall and the state of tissue colloids are a common cause of the hydropic state of the body. Along with the violation of protein metabolism, changes in the state of lipoid-cholesterol metabolism occur in the body with nephrosis. The absence of contraindications for giving nephrotic protein is well known.