Place of nuclease activity in antiviral defense

At the first stage of viral-cell interaction, the body's immune barrier cannot resist viral infections due to the absence of antibodies, which are known to be produced at a later date [18]. In this period, the body's nuclease activity is its earlier response than antibody formation [4], and functions as a natural antiviral defense mechanism that prevents the virus from entering the body and promotes its release from viral nucleic acids [18] and viral ribonucleoproteins migrating into the cellular space. [14]. Other authors also speak about the possible participation of nucleases in the formation and maintenance of the natural mechanisms of the body's antiviral defense, in particular, the digestive and respiratory systems against viral infections [3, 8]. The nuclease reaction is characterized by the absence of specificity and manifests itself in various pathological conditions [15].