Magnesium metabolism disorder in rickets-like diseases

Rickets-like diseases are inherited metabolic disorders. The most common forms of these diseases are vitamin-E-dependent rickets, Debret de Tony-Fanconi disease, and vitamin-D-resistant rickets. Their differential diagnosis is still very difficult because the clinical and radiological picture of these forms is very similar. All forms of rickets-like diseases are characterized by significant metabolic disorders and primarily phosphorus-calcium metabolism. A large role in metabolic processes in the body plays magnesium as an activator of many enzymes, in particular alkaline phosphatase and pyrophosphatase, directly related to the process of mineralization of bone tissue. A number of authors note the close relationship of magnesium metabolism with phosphorus-calcium metabolism. However, magnesium metabolism in rickets-like diseases has been insufficiently studied; the magnesium level in the blood was determined only in individual patients.