Determination of uropepsin in patients with gastrointestinal diseases

In recent years, there has been an increasing interest in the determination of uropepsin as one of the methods of functional diagnostics of the stomach. For the first time, pepsin in urine was discovered by the German scientist Brücke in 1861, and Mia and Belfanty (1886) called the substance in urine that digests fibrin, uropepsin. It was proved by Sali that pepsin is constantly contained in normal urine and that the amount of it during the day is subject to fluctuations, depending on the meals (maximum - before breakfast, minimum - after lunch). At the same time, it was suggested that urine contains not pure pepsin, but pepsinogen, since pepsin is destroyed in an alkaline environment.