On the relationship of local cellular immune reactions with spontaneous tumor necrosis

It is known that tumors cause a specific immune response of the body, carried out by both humoral antibodies and cellular factors [4]. At the same time, the main role in the immune effect on the tumor is played by activated thymus-dependent lymphocytes, which have a toxic effect on tumor cells [7, 8]. According to modern concepts, we are talking about the development of a delayed-type hypersensitivity immune reaction (HRT) [3]. Based on this, many authors tend to consider intense lymphoid-cell infiltrates in the tumor as a manifestation of the body's immune response [1], and the prognosis is considered better with a larger number of lymphocytes [6]. However, other researchers [5] believe that it is impossible to link the degree of lymphoid infiltration of the tumor with the prognosis. At the same time, it was found that immune reactions to the tumor are observed in 80% of cases, and in 2.5% the authors note the death of almost the entire tumor parenchyma [2].