Pharmacological studies of the uterine appendages at various physiological moments

Pharmacological studies of the uterine appendages at various physiological moments were carried out by Fujuta (according to Berich. Ü. Dg Gyn., Bd. XIV, H. 8), studying the effect of various poisons and medicines on the surviving tubes, round ligaments and the uterus of a rabbit in various generative phases: immature, mature, at the beginning and at the end of pregnancy and in the postpartum period .. F. comes to the conclusion that adrenaline, pilocarpine, quinine, nicotine, pituitrin, etc. not only have a different effect on the tested organs in connection with different physiological moments , but the same drug at the same time has a different effect on the tubes, round ligaments and uterus. The action of the drug is expressed either by excitement (E), then by inhibition (H), then the drug remains without effect on the organs (0). Pilocarpine is produced at lig. rotunda in all: stages of inhibition (H), on the tubes — weak excitement, on the uterus there is always strong excitement. Pituitrin in ligg. rot. in the late stages of pregnancy produces N., in the uterus — E., does not act on the tubes (0). Adrenaline on ligg. rot. and pipes in the immature period almost always has an effect E, on the uterus in the postpartum period H. Based on the results of experiments with adrenaline and pilocarpine, the author comes to the conclusion that ligg. rotunda and tubes are equipped with two kinds of sympathetic fibers, and at an immature age, inhibitory fibers are more sensitive than excitatory, during pregnancy, the relationship is reversed. In addition, due to the loss of reaction with pilocarpine (H. - ligg. Rot. And pipes), it can be assumed that the parasympathetic fibers are either little sensitive, or there are fewer of them in the pipes and ligg. rot., than in the uterus, and maybe they are completely absent. Since physostigmine, in contrast to pilocarpine, always excites, the author suggests that, in addition to the effect on the nerves, there is also the effect of these funds on the muscle.