Kubiczek, M. Pain-relieving effect of cobra venom (Polska gaz. Jek. 3-5. 1936)

Material a. is 23 sl .; in order to avoid the toxic effect of the poison, the dose during the first injection should not exceed 2.5 IU. Further dosage depends on the case and the nature of the action; the pause between individual injections should be at least 3 days, and the maximum dose should not exceed 20 IU. Cobra venom has no effect on pain caused by pressure on nerve endings and trunks; a good result can be expected with trigeminal neuralgia, sciatica, etc. It must be assumed that in such cases, cobra venom is not only an analgesic, but also a means of irritating therapy. If after the first injection, symptoms of anaphylaxis, edema, urticaria and itching develop, then further treatment is contraindicated; the same applies to the first symptoms of poisoning (nausea, vomiting and general weakness). Treatment with cobra venom is contraindicated in severe patients with uncompensated heart defects, lung diseases, acute kidney disease and advanced neoplasms.